ArticleScientific reports2016
Polyamine transporter in Streptococcus pneumoniae is essential for evading early innate immune responses in pneumococcal pneumonia.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Characterization of an Arginine Decarboxylase fromBiomolecules · 2024Article
- Role of the polyamine transporter PotABCD during biofilm formation by Streptococcus pneumoniae.PloS one · 2024Article
- Availability of polyamines affects virulence and survival of Neisseria meningitidis.Journal of microbiology (Seoul, Korea) · 2022Article
- Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis.Journal of cellular and molecular medicine · 2022Article
- Probiotic induced synthesis of microbiota polyamine as a nutraceutical for metabolic syndrome and obesity-related type 2 diabetes.Frontiers in endocrinology · 2022Review
- The Effect of Impaired Polyamine Transport on Pneumococcal Transcriptome.Pathogens (Basel, Switzerland) · 2021Article
- The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae.Pneumonia (Nathan Qld.) · 2021Review
- Arginine Decarboxylase Is Essential for Pneumococcal Stress Responses.Pathogens (Basel, Switzerland) · 2021Article
- Article
- SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis inFrontiers in microbiology · 2020Article
- Short-chain diamines are the physiological substrates of PACE family efflux pumps.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Role of Cadaverine Synthesis on Pneumococcal Capsule and Protein Expression.Medical sciences (Basel, Switzerland) · 2018Article
- Changed Expression of Cytoskeleton Proteins During Lung Injury in a Mouse Model ofFrontiers in microbiology · 2018Article
- Polyamine transporter potABCD is required for virulence of encapsulated but not nonencapsulated Streptococcus pneumoniae.PloS one · 2017Article
- Epidemiology, virulence factors and management of the pneumococcus.F1000Research · 2016Review
- Reprioritization of biofilm metabolism is associated with nutrient adaptation and long-term survival ofNPJ biofilms and microbiomesArticle
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Streptococcus pneumoniae is the most common bacterial etiology of pneumococcal pneumonia in adults worldwide. Genomic plasticity, antibiotic resistance and extreme capsular antigenic variation complicates the design of effective therapeutic strategies. Polyamines are ubiquitous small cationic molecules necessary for full expression of pneumococcal virulence. Polyamine transport system is an attractive therapeutic target as it is highly conserved across pneumococcal serotypes. In this study, we compared an isogenic deletion strain of S. pneumoniae TIGR4 in polyamine transport operon (ΔpotABCD) with the wild type in a mouse model of pneumococcal pneumonia. Our results show that the wild type persists in mouse lung 24 h post infection while the mutant strain is cleared by host defense mechanisms. We show that intact potABCD is required for survival in the host by providing resistance to neutrophil killing. Comparative proteomics analysis of murine lungs infected with wild type and ΔpotABCD pneumococci identified expression of proteins that could confer protection to wild type strain and help establish infection. We identified ERM complex, PGLYRP1, PTPRC/CD45 and POSTN as new players in the pathogenesis of pneumococcal pneumonia. Additionally, we found that deficiency of polyamine transport leads to up regulation of the polyamine synthesis genes speE and cad in vitro.
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