Evidence map›Paper›PMID 27246950›Full record

ArticleInternational journal of computer assisted radiology and surgery2016

Robotic-assisted real-time MRI-guided TAVR: from system deployment to in vivo experiment in swine model.

Joshua L Chan, Dumitru Mazilu, Justin G Miller, Timothy Hunt, Keith A Horvath, Ming Li

Open access · greenAbstract read
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  6. Multi-Modality Imaging in the Evaluation and Treatment of Tricuspid Regurgitation.Current treatment options in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joshua L ChanCardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D47, MSC 1550, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0001-7220-561X
Dumitru MaziluCardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D47, MSC 1550, 10 Center Drive, Bethesda, MD, 20892, USA.
Justin G MillerCardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D47, MSC 1550, 10 Center Drive, Bethesda, MD, 20892, USA.
Timothy HuntCardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D47, MSC 1550, 10 Center Drive, Bethesda, MD, 20892, USA.
Keith A HorvathCardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D47, MSC 1550, 10 Center Drive, Bethesda, MD, 20892, USA.
Ming LiCardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D47, MSC 1550, 10 Center Drive, Bethesda, MD, 20892, USA. lim2@mail.nih.gov.
National Institutes of Health · US

Funding

NHLBI Animal Program DivisionZIGHL006020 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CLARK, TANNIA · 2009 to 2025
$47.3M
Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

purposeReal-time magnetic resonance imaging (rtMRI) guidance provides significant advantages during transcatheter aortic valve replacement (TAVR) as it provides superior real-time visualization and accurate device delivery tracking. However, performing a TAVR within an MRI scanner remains difficult due to a constrained procedural environment. To address these concerns, a magnetic resonance (MR)-compatible robotic system to assist in TAVR deployments was developed. This study evaluates the technical design and interface considerations of an MR-compatible robotic-assisted TAVR system with the purpose of demonstrating that such a system can be developed and executed safely and precisely in a preclinical model.

methodsAn MR-compatible robotic surgical assistant system was built for TAVR deployment. This system integrates a 5-degrees of freedom (DoF) robotic arm with a 3-DoF robotic valve delivery module. A user interface system was designed for procedural planning and real-time intraoperative manipulation of the robot. The robotic device was constructed of plastic materials, pneumatic actuators, and fiber-optical encoders.

resultsThe mechanical profile and MR compatibility of the robotic system were evaluated. The system-level error based on a phantom model was 1.14 ± 0.33 mm. A self-expanding prosthesis was successfully deployed in eight Yorkshire swine under rtMRI guidance. Post-deployment imaging and necropsy confirmed placement of the stent within 3 mm of the aortic valve annulus.

conclusionsThese phantom and in vivo studies demonstrate the feasibility and advantages of robotic-assisted TAVR under rtMRI guidance. This robotic system increases the precision of valve deployments, diminishes environmental constraints, and improves the overall success of TAVR.

Indexed as

AnimalsAortic ValveFluoroscopyHeart Valve ProsthesisMagnetic Resonance ImagingPhantoms, ImagingProsthesis DesignRobotic Surgical ProceduresStentsSurgery, Computer-AssistedSwineTranscatheter Aortic Valve ReplacementCardiac surgeryMagnetic resonanceMRIRobotic assistanceTAVRValve replacement

Identifiers

PMID27246950
PMCPMC6524142
OpenAlexW2466506434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.