ArticleBMC complementary and alternative medicine2016
Assessment of antioxidant, anticancer and antimicrobial activity of two vegetable species of Amaranthus in Bangladesh.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 87 citations in OpenAlex.
- Multifunctional Edible Amaranths: A Review of Nutritional Benefits, Anti-Nutritional Factors, and Potential in Sustainable Food Systems.Foods (Basel, Switzerland) · 2026Review
- Analysis of Protein Inhibitors of Trypsin in Quinoa, Amaranth and Lupine Seeds. Selection and Deep Structure-Function Characterization of theInternational journal of molecular sciences · 2025Article
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- The interactive effects of drought and heat stress on photosynthetic efficiency and biochemical defense mechanisms ofPlant-environment interactions (Hoboken, N.J.) · 2022Article
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- Colorant Pigments, Nutrients, Bioactive Components, and Antiradical Potential of Danta Leaves (Antioxidants (Basel, Switzerland) · 2022Article
- SAXS Analysis and Characterization of Anticancer Activity of PNP-UDP Family Protein from Putranjiva roxburghii.The protein journal · 2022Article
- Characterization of Phytochemicals, Nutrients, and Antiradical Potential in Slim Amaranth.Antioxidants (Basel, Switzerland) · 2022Article
- Phytonutrients, Colorant Pigments, Phytochemicals, and Antioxidant Potential of Orphan LeafyMolecules (Basel, Switzerland) · 2022Article
- Isolation ofBiomass conversion and biorefinery · 2022Article
- The Dual Nature of Amaranth-Functional Food and Potential Medicine.Foods (Basel, Switzerland) · 2022Review
- The edible plantToxicology reports · 2022Article
- Molecular identification and biological control ofSaudi journal of biological sciences · 2021Article
- Amaranth Supplementation Improves Hepatic Lipid Dysmetabolism and Modulates Gut Microbiota in Mice Fed a High-Fat Diet.Foods (Basel, Switzerland) · 2021Article
- A comparative study of biological potentiality and EAC cell growth inhibition activity ofSaudi journal of biological sciences · 2021Article
- Deciphering the molecular pathways of apoptosis using purified fractions from leaf extract of Basella alba through studying the regulation of apoptosis related genes.Molecular biology reports · 2021Article
- A Review of Recent Studies on the Antioxidant Activities of a Third-Millennium Food:Antioxidants (Basel, Switzerland) · 2020Review
- Effects of Ultra-Sonication and Agitation on Bioactive Compounds and Structure of Amaranth Extract.Foods (Basel, Switzerland) · 2020Article
- In-vivo antiproliferative activity ofToxicological research · 2020Article
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmaranthus (Amaranthaceae) has previously been reported to possess different bioactive phytochemicals including phenols, tannins and flavonoids. The current study was designed to evaluate the antioxidant, anti-proliferative and antimicrobial activity of stem and seed extracts of Amaranthus lividus (AL) and Amaranthus hybridus (AH), respectively.
methodsAntioxidant activity of methanol extract was assessed by DPPH radical scavenging assay. Determination of lectin activity of Amaranthus extract was carried out using hemagglutination assay on mouse blood. A total of thirty six Swiss albino mice containing Ehrlich's ascites carcinoma (EAC) cells were treated with AL and AH extract at 25, 50 and 100 μg/ml/day/mouse for six days. Growth inhibitory activity was determined by haemocytometer counting of EAC cells using trypan blue dye and DAPI (4΄,6-diamidino-2-phenylindole) staining was used to assess apoptotic cells. Gene amplification study was conducted to observe the expression pattern of p53, Bax, Bcl-2 and caspase-3 mRNA using PCR (polymer chain reaction) technique. In vitro susceptibility of five pathogenic bacteria including Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Salmonella typhi and Staphylococcus aureus was detected using disk diffusion assay.
resultsThe radical scavenging assay indicated that AH and AL possesses potent antioxidant potential, exhibiting IC50 value of 28 ± 1.5 and 93 ± 3.23 μg/ml, respectively. Hemagglutination assay revealed that AH and AL agglutinated mice blood at 1.565 and 3.125 μg/wall, respectively. Administration of AH and AL extract led to 45 and 43 % growth inhibition of EAC cells, respectively at 100 μg/ml with marked features of apoptosis including cell shrinkage, condensation of cytoplasm and aggregation of apoptotic bodies etc. Up-regulation of p53, Bax and caspase-3 and down-regulation of Bcl-2 mRNA in Amaranthus treated mice indicated mitochondria mediated apoptosis of EAC cells in comparison with control. None of the bacterial species showed susceptibility to the extract of both the Amaranthus species.
conclusionOur current findings suggest that both of the Amaranthus species have strong antioxidant, lectin and anti-proliferative activity on EAC cells. The current anticancer potential was observed due mainly to the mitochondria mediated apoptosis of EAC cells.
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