Evidence map›Paper›PMID 27246710›Full record

ReviewDevelopment (Cambridge, England)2016

Circular RNAs: analysis, expression and potential functions.

Steven P Barrett, Julia Salzman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 499 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
499citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

499 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  15. Identification of circRNAs in industrial hemp (Frontiers in plant science · 2026
    Article
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439 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Steven P BarrettDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7120-8365
Julia SalzmanDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA Julia.salzman@stanford.edu.

Funding

Unbiased discovery of mechanisms regulating circRNAR01GM116847 · NIGMS · STANFORD UNIVERSITY · PI SALZMAN, JULIA · 2015 to 2019
$1.6M
Discovering genomic rearrangements under selection in serious ovarian cancerR00CA168987 · NCI · STANFORD UNIVERSITY · PI SALZMAN, JULIA · 2014 to 2016
$704k
NCI NIH HHS R00 CA168987NIGMS NIH HHS R01 GM116847
6 · The paper itself

Abstract

Just a few years ago, it had been assumed that the dominant RNA isoforms produced from eukaryotic genes were variants of messenger RNA, functioning as intermediates in gene expression. In early 2012, however, a surprising discovery was made: circular RNA (circRNA) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RNA isoform. Subsequent studies revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific, and shared across the eukaryotic tree of life. These features suggest important functions for these molecules. Here, we describe major advances in the field of circRNA biology, focusing on the regulation of and functional roles played by these molecules.

Indexed as

Gene Expression RegulationAnimalsComputational BiologyHumansModels, GeneticRNARNA, CircularRNA SplicingRNARNA, CircularCircRNADevelopmentNon-coding RNARegulationSplicing

Identifiers

PMID27246710
PMCPMC4920157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.