ArticleFluids and barriers of the CNS2016
MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro.
Article in Fluids and barriers of the CNS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Modeling Brain Vasculature Immune Interactions In Vitro.Cold Spring Harbor perspectives in medicine · 2023Review
- Minor Changes for a Major Impact: A Review of Epigenetic Modifications in Cell-Based Therapies for Stroke.International journal of molecular sciences · 2022Review
- MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin glycoside alters immunogenic and oncogenic profiles of breast cancer.Molecular and cellular biochemistry · 2022Article
- Non-coding RNAs in the regulation of blood-brain barrier functions in central nervous system disorders.Fluids and barriers of the CNS · 2022Review
- Pathophysiology of Atherosclerosis.International journal of molecular sciences · 2022Review
- Zika Virus NS1 Suppresses VE-Cadherin and Claudin-5 via hsa-miR-101-3p in Human Brain Microvascular Endothelial Cells.Molecular neurobiology · 2021Article
- Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation.Pharmaceutics · 2021Article
- miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review.International journal of molecular sciences · 2021Review
- The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.Microbes and infection · 2020Article
- MicroRNAs: Possible Regulatory Molecular Switch Controlling the BBB Microenvironment.Molecular therapy. Nucleic acids · 2020Article
- Tumor Necrosis Factor-alpha (TNF-α) Enhances miR-155-Mediated Endothelial Senescence by Targeting Sirtuin1 (SIRT1).Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- MicroRNA-155 induces protection against cerebral ischemia/reperfusion injury through regulation of the Notch pathwayExperimental and therapeutic medicine · 2019Article
- Involvement of Epigenetic Mechanisms and Non-coding RNAs in Blood-Brain Barrier and Neurovascular Unit Injury and Recovery After Stroke.Frontiers in neuroscience · 2019Review
- MicroRNA-155 Controls T Helper Cell Activation During Viral Infection.Frontiers in immunology · 2019Article
- MicroRNAs as Potential Mediators for Cigarette Smoking Induced Atherosclerosis.International journal of molecular sciences · 2018Article
- Extracellular vesicles regulate immune responses and cellular function in intestinal inflammation and repair.Tissue barriers · 2018Review
- Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation.Molecular neurobiology · 2017Review
- MicroRNA 155 and viral-induced neuroinflammation.Journal of neuroimmunology · 2017Review
- MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium.Scientific reports · 2017Article
- New experimental models of the blood-brain barrier for CNS drug discovery.Expert opinion on drug discovery · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased leukocyte adhesion to brain endothelial cells forming the blood-brain barrier (BBB) precedes extravasation into the central nervous system (CNS) in neuroinflammatory diseases such as multiple sclerosis (MS). Previously, we reported that microRNA-155 (miR-155) is up-regulated in MS and by inflammatory cytokines in human brain endothelium, with consequent modulation of endothelial paracellular permeability. Here, we investigated the role of endothelial miR-155 in leukocyte adhesion to the human cerebral microvascular endothelial cell line, hCMEC/D3, under shear forces mimicking blood flow in vivo.
resultsUsing a gain- and loss-of-function approach, we show that miR-155 up-regulation increases leukocyte firm adhesion of both monocyte and T cells to hCMEC/D3 cells. Inhibition of endogenous endothelial miR-155 reduced monocytic and T cell firm adhesion to naïve and cytokines-induced human brain endothelium. Furthermore, this effect is partially associated with modulation of the endothelial cell adhesion molecules VCAM1 and ICAM1 by miR-155.
conclusionsOur results suggest that endothelial miR-155 contribute to the regulation of leukocyte adhesion at the inflamed BBB. Taken together with previous observations, brain endothelial miR-155 may constitute a potential molecular target for treatment of neuroinflammation diseases.
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