Evidence map›Paper›PMID 27246624›Full record

ArticleChannels (Austin, Tex.)2016

FGF13 modulates the gating properties of the cardiac sodium channel Na

Jing Yang, Zhihua Wang, Daniel S Sinden, Xiangchong Wang, Bin Shan, Xiao Yu, Hailin Zhang, Geoffrey S Pitt, Chuan Wang

Open access · goldAbstract read
In one paragraph

Article in Channels (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jing Yanga Department of Physiology , Hebei Medical University , Shijiazhuang , Hebei , China.
Zhihua Wangb Department of Pharmacology , Hebei Medical University , Shijiazhuang , Hebei , China.
Daniel S Sindenc Department of Medicine/Cardiology and Pharmacology , Ion Channel Research Unit, Duke University Medical Center , Durham , NC , USA.
Xiangchong Wangb Department of Pharmacology , Hebei Medical University , Shijiazhuang , Hebei , China.
Bin Shanb Department of Pharmacology , Hebei Medical University , Shijiazhuang , Hebei , China.
Xiao Yud Department of Physiology , Shandong University, School of Medicine , Jinan , Shandong , China.
Hailin Zhangb Department of Pharmacology , Hebei Medical University , Shijiazhuang , Hebei , China.
Geoffrey S Pittc Department of Medicine/Cardiology and Pharmacology , Ion Channel Research Unit, Duke University Medical Center , Durham , NC , USA.
Chuan Wangb Department of Pharmacology , Hebei Medical University , Shijiazhuang , Hebei , China.
Hebei Medical University · CNDuke Medical Center · USDuke University Hospital · USShandong University · CN

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Calcium regulation and dysregulation of cardiac ion channelsR01HL071165 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2002 to 2017
$5.2M
Calmodulin regulation of Na+ channels in neurons and cardiomyocytesR01HL122967 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARX, STEVEN O, PITT, GEOFFREY S · 2015 to 2018
$2.1M
Structural studies of NaV1.5 and functional implications.R01HL112918 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL071165NHLBI NIH HHS R01 HL112918NHLBI NIH HHS R01 HL122967NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

FGF13 (FHF2), the major fibroblast growth factor homologous factor (FHF) in rodent heart, directly binds to the C-terminus of the main cardiac sodium channel, Na

Indexed as

Cell LineFibroblast Growth FactorsHumansIon Channel GatingNAV1.5 Voltage-Gated Sodium ChannelProtein Isoformsfibroblast growth factor 13Fibroblast Growth FactorsNAV1.5 Voltage-Gated Sodium ChannelProtein IsoformsactivationFGF13fibroblast growth factor homologous factorsgatinginactivationisoformNav1.5N-terminirecovery from inactivationvoltage gated sodium channels

Identifiers

PMID27246624
PMCPMC4988462
OpenAlexW2412690797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.