Evidence map›Paper›PMID 27246604›Full record

Trial reportBMC infectious diseases2016

HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection.

François M J Lamoury, Behzad Hajarizadeh, Elizabeth Keoshkerian, Jordan J Feld, Janaki Amin, Suzy Teutsch, Gail V Matthews, Margaret Hellard, Gregory J Dore, Andrew R Lloyd and 3 more

Registry-linked trialOpen access · goldAbstract readClinical TrialMulticenter Study

PubMed Full text at PMC Publisher

In one paragraph

Trial report in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00192569 (Australian Trial in Acute Hepatitis C), which is not on this map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

0.7field-weighted citation impact, top 27% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00192569 phase4completednot on this map

Australian Trial in Acute Hepatitis C

TypeinterventionalSponsorKirby InstituteRan2004 to 2010Enrolled167ConditionsHepatitis CArmsPegylated Interferon alfa 2a, Ribavirin (HIV conifected patients only)

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

Cytokine profiles as predictors of HIV incidence using machine learning survival models and statistical interpretable techniques.Scientific reports · 2024
Article
Infection with HIV-1 subtype D among acutely infected Ugandans is associated with higher median concentration of cytokines compared to subtype A.IJID regions · 2022
Article
Simian Immunodeficiency Virus Infection Mediated Changes in Jejunum and Peripheral SARS-CoV-2 Receptor ACE2 and Associated Proteins or Genes in Rhesus Macaques.Frontiers in immunology · 2022
Article
Inflammatory biomarker levels over 48 weeks with dual vs triple lopinavir/ritonavir-based therapy: Substudy of a randomized trial.PloS one · 2019
Article
Update in HIV-hepatitis C virus coinfection in the direct acting antiviral era.Current opinion in gastroenterology · 2017
Review
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid.Open forum infectious diseases · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

François M J LamouryThe Kirby Institute, UNSW Australia, Sydney, Australia. flamoury@kirby.unsw.edu.au.

Behzad HajarizadehThe Kirby Institute, UNSW Australia, Sydney, Australia.

Elizabeth KeoshkerianInflammation and Infection Research Centre, School of Medical Sciences, UNSW Australia, Sydney, Australia.

Jordan J FeldToronto Centre for Liver Disease, McLaughlin-Rotman Centre for Global Health, University of Toronto, Toronto, Canada.

Janaki AminThe Kirby Institute, UNSW Australia, Sydney, Australia.

Suzy TeutschInflammation and Infection Research Centre, School of Medical Sciences, UNSW Australia, Sydney, Australia.

Gail V MatthewsThe Kirby Institute, UNSW Australia, Sydney, Australia.

Margaret HellardBurnet Institute, Melbourne, Australia.

Gregory J DoreThe Kirby Institute, UNSW Australia, Sydney, Australia.

Andrew R LloydInflammation and Infection Research Centre, School of Medical Sciences, UNSW Australia, Sydney, Australia.

Tanya L ApplegateThe Kirby Institute, UNSW Australia, Sydney, Australia.

Jason GrebelyThe Kirby Institute, UNSW Australia, Sydney, Australia.

ATAHC Study Group

UNSW Sydney · AUBurnet Institute · AUUniversity of Toronto · CA

Funding

Treatment of recently acquired hepatitis C virus infectionR01DA015999 · NIDA · UNIVERSITY OF NEW SOUTH WALES · PI DORE, GREGORY JOHN · 2003 to 2014

$3.7M

NIDA NIH HHS R01 DA015999

6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV) infection leads to more rapid progression of hepatitis C virus (HCV)-related liver fibrosis, which could be linked to differences in the severity of liver inflammation among HIV/HCV co-infected individuals compared to HCV mono-infected individuals. This study assessed the association of HIV co-infection with pro-inflammatory and pro-fibrogenic cytokines and chemokines during recent HCV infection.

methodsParticipants from the ATAHC study, a prospective cohort of recent HCV infection, with detectable HCV RNA at the time of acute HCV detection were included. Concentrations of 27 plasma cytokines and chemokines were measured by multiplex immunoassays and compared between those with, and without, HIV co-infection.

resultsOut of 117 individuals with recent HCV infection included in analysis, 73 had HCV mono-infection and 44 had HIV/HCV co-infection. Individuals with HIV/HCV co-infection had significantly higher mean levels of eotaxin (1.79 vs. 1.62 log pg/mL; P < 0.001), monocyte chemotactic protein 1 (MCP-1; 2.10 vs. 1.98 log pg/mL; P < 0.001), and interferon-gamma inducible protein-10 (IP-10; 3.11 vs. 2.98 log pg/mL; P = 0.013). Linear regression analyses adjusting for age, alanine transaminase (ALT), HCV RNA levels, and assay run, higher eotaxin levels were independently associated with HIV/HCV co-infection (adjusted β: 0.12; 95%CI: 0.01, 0.24; P = 0.039). Higher MCP-1 levels were also independently associated with HIV/HCV co-infection in adjusted analysis (adjusted β: 0.11; 95%CI: 0.03, 0.18; P = 0.009).

conclusionsDuring recent HCV, those with HIV/HCV co-infection had a stronger pro-fibrogenic mediator profile compared to those with HCV mono-infection. These findings may provide a potential explanation for accelerated liver fibrosis in HIV/HCV co-infection.

trial registrationAustralian Trial in Acute Hepatitis C (ATAHC) study was registered with ClinicalTrials.gov registry on September 11, 2005. NCT00192569 .

Indexed as

AdultAlanine TransaminaseAustraliaChemokine CCL11Chemokine CCL2CoinfectionFemaleHepacivirusHepatitis CHIV-1HIV InfectionsHumansInterferon-gammaMaleMiddle AgedYoung AdultAlanine TransaminaseCCL11 protein, humanCCL2 protein, humanChemokine CCL11Chemokine CCL2Interferon-gammaAcute infectionChemokinesCo-infectionCytokinesHCV

Identifiers

PMID27246604

DOI10.1186/s12879-016-1567-2

PMCPMC4888248

OpenAlexW2411160576

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

NCT00192569ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.