ArticleThe Journal of allergy and clinical immunology2016
Sex-specific risk factors for childhood wheeze and longitudinal phenotypes of wheeze.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Trial
- Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation.The journal of allergy and clinical immunology. In practice · 2019Trial
- Insights into the relationship between nasal bacterial composition and susceptibility to early-life respiratory disease: a pilot observational study.medRxiv : the preprint server for health sciences · 2025Article
- Bayesian additive regression trees for predicting childhood asthma in the CHILD cohort study.BMC medical research methodology · 2024Article
- Clinical predictors of wheeze trajectories and associations with allergy in Asian children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Clinical features and later prognosis of replicable early-life wheeze clusters from two birth cohorts 12 years apart.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- Human Milk Metabolomics Are Related to Maternal Adiposity, Infant Growth Rate and Allergies: The Chinese Human Milk Project.Nutrients · 2022Article
- Early Bronchiolitis Contributes to Preschool Asthma.Children (Basel, Switzerland) · 2021Article
- Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.American journal of respiratory and critical care medicine · 2021Article
- Wheezing-Related Relevant Factors and the Role of Viral Bronchiolitis.Frontiers in allergy · 2021Review
- Gender medicine: Lessons from COVID-19 and other medical conditions for designing health policy.World journal of clinical cases · 2020Review
- Associations of Prenatal Dietary Inflammatory Potential with Childhood Respiratory Outcomes in Project Viva.The journal of allergy and clinical immunology. In practice · 2020Article
- Characterization of longitudinal wheeze phenotypes from infancy to adolescence in Project Viva, a prebirth cohort study.The Journal of allergy and clinical immunology · 2020Article
- Prenatal and early-life triclosan and paraben exposure and allergic outcomes.The Journal of allergy and clinical immunology · 2018Article
- Article
- Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children.BMC pulmonary medicine · 2017Article
- Recent advances in understanding and managing asthma.F1000Research · 2016Review
- Changes in body mass index during early childhood on school-age asthma prevalence classified by phenotypes and sex.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough sexual dimorphism in wheeze and asthma prevalence are well documented, sex-specific risk factors for wheeze and longitudinal wheeze phenotypes have not been well elucidated.
objectiveBy using a large prebirth cohort, this study aimed to identify sex-specific risk factors for wheeze from birth through midchildhood and identify distinct longitudinal wheeze phenotypes and the sex-specific risk factors associated with these phenotypes.
methodsMothers reported child wheeze symptoms over the past year approximately yearly on 9 occasions starting at age 1 year. We identified sex-specific predictors of wheeze, wheeze phenotypes, and sex-specific predictors of these phenotypes by using generalized estimating equations, latent class mixed models, and multinomial logistic analysis, respectively.
resultsA total of 1623 children had information on wheeze at 1 or more time points. Paternal asthma was a stronger predictor of ever wheezing in boys (odds ratio [OR], 2.15; 95% CI, 1.74-2.66) than in girls (OR, 1.53; 95% CI, 1.19-1.96; P for sex by paternal asthma interaction = .03), whereas being black or Hispanic, birth weight for gestational age z score, and breast-feeding duration had stronger associations among girls. We identified 3 longitudinal wheeze phenotypes: never/infrequent wheeze (74.1%), early transient wheeze (12.7%), and persistent wheeze (13.1%). Compared with never/infrequent wheeze, maternal asthma, infant bronchiolitis, and atopic dermatitis were associated with persistent wheeze in both sexes, but paternal asthma was associated with persistent wheeze in boys only (OR, 4.27; 95% CI, 2.33-7.83; P for sex by paternal asthma interaction = .02), whereas being black or Hispanic was a predictor for girls only.
conclusionWe identified sex-specific predictors of wheeze and longitudinal wheeze patterns, which might have important prognostic value and allow for a more personalized approach to wheeze and asthma treatment.
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