ArticleScientific reports2016
Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Electrochemical Sulfite Sensing: Current Trends and Challenges in Food Quality Control and Real Samples.Foods (Basel, Switzerland) · 2026Review
- Toxic Effects of Sulfur Dioxide: A Review.Toxics · 2026Review
- A multifunctional AIE probe with dual organelle targeting and without crosstalk for the simultaneous detection of SOMikrochimica acta · 2025Article
- Sulfur dioxide inhibits mast cell degranulation by sulphenylation of galectin-9 at cysteine 74.Frontiers in immunology · 2024Article
- Advances in the research of sulfur dioxide and pulmonary hypertension.Frontiers in pharmacology · 2023Review
- Role of Militarine in PMNeurochemical research · 2021Article
- Endogenous SORedox biology · 2021Article
- Effect of sulfur dioxide on vascular biology.Histology and histopathology · 2021Review
- Endothelial Cell-Derived SOOxidative medicine and cellular longevity · 2021Article
- Plasma Endogenous Sulfur Dioxide: A Novel Biomarker to Predict Acute Kidney Injury in Critically Ill Patients.International journal of general medicine · 2021Article
- PPARMediators of inflammation · 2019Article
- Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.Molecular medicine reports · 2017Article
- Perivascular adipose tissue: epiphenomenon or local risk factor?International journal of obesity (2005) · 2017Review
- Astragalus polysaccharides attenuates TNF-α-induced insulin resistance via suppression of miR-721 and activation of PPAR-γ and PI3K/AKT in 3T3-L1 adipocytes.American journal of translational research · 2017Article
- Hydrogen Sulfide in the Adipose Tissue-Physiology, Pathology and a Target for Pharmacotherapy.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was designed to determine whether sulfur dioxide (SO2) could be endogenously produced in adipocyte and served as a novel adipocyte-derived inflammatory inhibitor. SO2 was detected in adipose tissue using high-performance liquid chromatography with fluorescence detection. SO2 synthase aspartate aminotransferase (AAT1 and AAT2) mRNA and protein expressions in adipose tissues were measured. For in vitro study, 3T3-L1 adipocytes were cultured, infected with adenovirus carrying AAT1 gene or lentivirus carrying shRNA to AAT1, and then treated with tumor necrosis factor-α (TNF-α). We found that endogenous SO2/AAT pathway existed in adipose tissues including perivascular, perirenal, epididymal, subcutaneous and brown adipose tissue. AAT1 overexpression significantly increased SO2 production and inhibited TNF-α-induced inflammatory factors, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) secretion from 3T3-L1 adipocytes. By contrast, AAT1 knockdown decreased SO2 production and exacerbated TNF-α-stimulated MCP-1 and IL-8 secretion. Mechanistically, AAT1 overexpression attenuated TNF-α-induced IκBα phosphorylation and degradation, and nuclear factor-κB (NF-κB) p65 phosphorylation, while AAT1 knockdown aggravated TNF-α-activated NF-κB pathway, which was blocked by SO2. NF-κB inhibitors, PDTC or Bay 11-7082, abolished excessive p65 phosphorylation and adipocyte inflammation induced by AAT1 knockdown. This is the first report to suggest that endogenous SO2 is a novel adipocyte-derived inflammatory inhibitor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.