Evidence map›Paper›PMID 27246240›Full record

ArticleCardiovascular ultrasound2016

Echocardiographic markers of inducible myocardial ischemia at baseline evaluation preparatory to exercise stress echocardiography.

Antonella Cherubini, Giovanni Cioffi, Carmine Mazzone, Giorgio Faganello, Giulia Barbati, Luigi Tarantini, Giulia Russo, Carlo Stefenelli, Franco Humar, Eliana Grande and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular ultrasound, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Antonella CherubiniCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Giovanni CioffiCardiology Department Villa Bianca Hospital, Trento, Italy. gcioffi@villabiancatrento.it.
Carmine MazzoneCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Giorgio FaganelloCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Giulia BarbatiCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Luigi TarantiniCardiology Department St. Martino Hospital Azienda Sanitaria Locale n. 1, Belluno, Italy.
Giulia RussoCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Carlo StefenelliCardiology Department Villa Bianca Hospital, Trento, Italy.
Franco HumarCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Eliana GrandeCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Maurizio FisicaroCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Claudio PandulloCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
Andrea Di LenardaCardiovascular Center, Health Authority n° 1 and University of Trieste, Trieste, Italy.
University of Trieste · ITCasa di Cura Villa Bianca · ITASL Roma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTissue Doppler Imaging (TDI) is a sensible and feasible method to detect longitudinal left ventricular (LV) systolic dysfunction (LVSD) in patients with diabetes mellitus, hypertension or ischemic heart disease. In this study, we hypothesized that longitudinal LVSD assessed by TDI predicted inducible myocardial ischemia independently of other echocardiographic variables (assessed as coexisting potential markers) in patients at increased cardiovascular (CV) risk.

methodsTwo hundred one patients at high CV risk defined according to the ESC Guidelines 2012 underwent exercise stress echocardiography (ExSEcho) for primary prevention. Echocardiographic parameters were measured at rest and peak exercise.

resultsExSEcho classified 168 (83.6 %) patients as non-ischemic and 33 (16,4 %) as ischemic. Baseline clinical characteristics were similar between the groups, but ischemic had higher blood pressure, received more frequently beta-blockers and antiplatelet agents than non-ischemic patients. The former had greater LV size, lower relative wall thickness and higher left atrial systolic force (LASF) than the latter. LV systolic longitudinal function (measure as peak S') was significantly lower in ischemic than non-ischemic patients (8.7 ± 2.1 vs 9.7 ± 2.7 cm/sec, p = 0.001). The factors independently related to myocardial ischemia at multivariate logistic analysis were: lower peak S', higher LV circumferential end-systolic stress and LASF.

conclusionsIn asymptomatic patients at increased risk for adverse CV events baseline longitudinal LVSD together with higher LV circumferential end-systolic stress and LASF were the factors associated with myocardial ischemia induced by ExSEcho. The assessment of these factors at standard echocardiography might help the physicians for improving the risk stratification among these patients for ExSEcho.

Indexed as

AgedEchocardiography, DopplerEchocardiography, StressExercise TestFemaleHumansMaleMyocardial IschemiaRetrospective StudiesVentricular Function, LeftCardiovascular riskExercise stress testInducible myocardial ischemiaLeft ventricular systolic functionLongitudinal function

Identifiers

PMID27246240
PMCPMC4888406
OpenAlexW2409413763

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.