Evidence map›Paper›PMID 27246095›Full record

ArticlePlant physiology2016

The ROS Wheel: Refining ROS Transcriptional Footprints.

Patrick Willems, Amna Mhamdi, Simon Stael, Veronique Storme, Pavel Kerchev, Graham Noctor, Kris Gevaert, Frank Van Breusegem

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
33.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 152 citations in OpenAlex.

  1. Article
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  11. Life (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. HAntioxidants (Basel, Switzerland) · 2022
    Article
  18. The Passage of HPlants (Basel, Switzerland) · 2022
    Review
  19. Review
  20. Hydrogen peroxide-induced stress acclimation in plants.Cellular and molecular life sciences : CMLS · 2022
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Patrick WillemsDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.).ORCID 0000-0003-4667-2294
Amna MhamdiDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.).ORCID 0000-0001-9959-1362
Simon StaelDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.).ORCID 0000-0001-8322-0428
Veronique StormeDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.).ORCID 0000-0003-4762-6580
Pavel KerchevDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.).ORCID 0000-0003-2737-0493
Graham NoctorDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.).
Kris GevaertDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.).ORCID 0000-0002-4237-0283
Frank Van BreusegemDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium (P.W., A.M., S.S., V.S., P.K., F.V.B.);Medical Biotechnology Center, VIB, 9000 Ghent, Belgium (P.W., S.S., K.G.);Department of Biochemistry, Ghent University, 9000 Ghent, Belgium (P.W., S.S., K.G.);Institut des Sciences des Plantes de Paris-Saclay, Unité Mixte de Recherche 8618, Centre National de la Recherche Scientifique, Université de Paris-Sud, 91405 Orsay cedex, France (A.M., G.N.); andUnité Mixte de Recherche 9213/Unité Mixte de Recherche 1403, Université Paris-Sud, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université d'Evry, Université Paris-Diderot, Sorbonne Paris-Cité, 91405 Orsay, France (A.M., G.N.) frank.vanbreusegem@psb.ugent.be.ORCID 0000-0002-3147-0860
Université Paris-Sud · FRGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decade, microarray studies have delivered extensive inventories of transcriptome-wide changes in messenger RNA levels provoked by various types of oxidative stress in Arabidopsis (Arabidopsis thaliana). Previous cross-study comparisons indicated how different types of reactive oxygen species (ROS) and their subcellular accumulation sites are able to reshape the transcriptome in specific manners. However, these analyses often employed simplistic statistical frameworks that are not compatible with large-scale analyses. Here, we reanalyzed a total of 79 Affymetrix ATH1 microarray studies of redox homeostasis perturbation experiments. To create hierarchy in such a high number of transcriptomic data sets, all transcriptional profiles were clustered on the overlap extent of their differentially expressed transcripts. Subsequently, meta-analysis determined a single magnitude of differential expression across studies and identified common transcriptional footprints per cluster. The resulting transcriptional footprints revealed the regulation of various metabolic pathways and gene families. The RESPIRATORY BURST OXIDASE HOMOLOG F-mediated respiratory burst had a major impact and was a converging point among several studies. Conversely, the timing of the oxidative stress response was a determining factor in shaping different transcriptome footprints. Our study emphasizes the need to interpret transcriptomic data sets in a systematic context, where initial, specific stress triggers can converge to common, aspecific transcriptional changes. We believe that these refined transcriptional footprints provide a valuable resource for assessing the involvement of ROS in biological processes in plants.

Indexed as

Gene Expression Regulation, PlantArabidopsisArabidopsis ProteinsGene Expression ProfilingModels, BiologicalMultigene FamilyOligonucleotide Array Sequence AnalysisOxidation-ReductionOxidative StressReactive Oxygen SpeciesTranscription, GeneticArabidopsis ProteinsReactive Oxygen Species

Identifiers

PMID27246095
PMCPMC4936575
OpenAlexW2460980543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.