ArticleThe journal of headache and pain2016
Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study.
Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Ketogenic Diet Normalizes Interictal Cortical But Not Subcortical Responsivity in Migraineurs
Randomized-controlled Study for Evaluation of Ketogenic Metabolic Nutritional Pattern in Subjects With High-frequency Episodic Migraine
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Ketosis and migraine: a systematic review of the literature and meta-analysis.Frontiers in nutrition · 2023Pooled it
- The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.Headache · 2020Pooled it
- Defining metabolic migraine with a distinct subgroup of patients with suboptimal inflammatory and metabolic markers.Scientific reports · 2023Trial
- A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones?Nutrients · 2019Trial
- Nutrition and Physical Activity in an Interdisciplinary Approach to Migraine: A Narrative Review.Nutrients · 2025Review
- Fasting and Headache.Current pain and headache reports · 2025Review
- Dietary Patterns and Migraine: Insights and Impact.Nutrients · 2025Review
- Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing.Frontiers in neurology · 2025Review
- Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance.Aging and disease · 2024Review
- Unraveling the MSG-Headache Controversy: an Updated Literature Review.Current pain and headache reports · 2024Review
- Case Series: Vestibular Migraines in Fragile X Premutation Carriers.Journal of clinical medicine · 2024Article
- A 1-month ketogenic diet in patients with migraine gives a clinical beneficial effect associated with increased latency of somatosensory thalamo-cortical activity.Clinical neurophysiology practice · 2024Article
- All Roads Lead to the Gut: The Importance of the Microbiota and Diet in Migraine.Neurology international · 2023Review
- Exploring sensory sensitivity, cortical excitability, and habituation in episodic migraine, as a function of age and disease severity, using the pattern-reversal task.The journal of headache and pain · 2023Article
- 2:1 ketogenic diet and low-glycemic-index diet for the treatment of chronic and episodic migraine: a single-center real-life retrospective study.The journal of headache and pain · 2023Article
- Migraine Prevention through Ketogenic Diet: More than Body Mass Composition Changes.Journal of clinical medicine · 2022Article
- Association between dietary acid load and clinical features of migraine headaches among Iranian individuals.Scientific reports · 2022Article
- Measuring ketone bodies for the monitoring of pathologic and therapeutic ketosis.Obesity science & practice · 2021Review
- Effectiveness of ketogenic diet in treatment of patients with refractory chronic migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration?Healthcare (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHere, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine.
methodsEighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before and after 1 month of KD during ketogenesis. We measured VEPs N1-P1 and SSEPs N20-P25 amplitudes respectively in six and in two sequential blocks of 100 sweeps as well as habituation as theslope of the linear regression between block 1 to 6 for VEPs or between 1 to 2 for SSEPs.
resultsAfter 1-month of KD, a significant reduction in the mean attack frequency and duration was observed (all P< 0.001). The KD did not change the 1st SSEP and VEP block of responses, but significantly inducednormalization of the interictally reduced VEPs and SSEPs (all p < 0.01) habituation during the subsequentblocks.
conclusionsKD could restore normal EPs habituation curves during stimulus repetition without significantly changing theearly amplitude responses. Thus, we hypothesize that KD acts on habituation regulating the balancebetween excitation and inhibition at the cortical level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.