ArticleScientific reports2016
Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Nontuberculous mycobacteria in gastrostomy fed patients with cystic fibrosis.Scientific reports · 2017Trial
- Effects of Helicobacter pylori infection on gastric mucosal microbiota.World journal of pediatrics : WJP · 2026Review
- Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission.Scientific reports · 2025Article
- A prospective study of extraesophageal reflux and potential microaspiration in patients hospitalized with COVID-19 in Jordan.BMC pulmonary medicine · 2023Article
- Exposure to bile and gastric juice can impact the aerodigestive microbiome in people with cystic fibrosis.Scientific reports · 2022Article
- Soil bacteria protect fungi from phenazines by acting as toxin sponges.Current biology : CB · 2022Article
- The Gut-Lung Axis in Cystic Fibrosis.Journal of bacteriology · 2021Review
- Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung.Antibiotics (Basel, Switzerland) · 2021Review
- Reply to WardAmerican journal of respiratory and critical care medicine · 2020Article
- Clonally Related Viable Nontuberculous Mycobacteria in Gastric Juice and Sputum in People with Cystic Fibrosis.American journal of respiratory and critical care medicine · 2020Article
- Parallel Analysis of Cystic Fibrosis Sputum and Saliva Reveals Overlapping Communities and an Opportunity for Sample Decontamination.mSystems · 2020Article
- The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks.Frontiers in cellular and infection microbiology · 2020Review
- Commensal Microbes Affect Host Humoral Immunity toInfection and immunity · 2019Article
- Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn's-Like Microbiota Disturbances.Journal of clinical medicine · 2019Article
- Dose-Dependent Effects of Aloin on the Intestinal Bacterial Community Structure, Short Chain Fatty Acids Metabolism and Intestinal Epithelial Cell Permeability.Frontiers in microbiology · 2019Article
- Exposure to Bile Leads to the Emergence of Adaptive Signaling Variants in the Opportunistic PathogenFrontiers in microbiology · 2019Article
- Article
- Gastric Aspiration and Its Role in Airway Inflammation.The open respiratory medicine journal · 2018Review
- Interaction betweenPeerJ · 2018Article
- The Gastric Microbiome Is Perturbed in Advanced Gastric Adenocarcinoma Identified Through Shotgun Metagenomics.Frontiers in cellular and infection microbiology · 2018Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
Gastro-Oesophageal Reflux (GOR) is a key problem in Cystic Fibrosis (CF), but the relationship between lung and gastric microbiomes is not well understood. We hypothesised that CF gastric and lung microbiomes are related. Gastric and sputum cultures were obtained from fifteen CF patients receiving percutaneous endoscopic gastrostomy feeding. Non-CF gastric juice data was obtained through endoscopy from 14 patients without lung disease. Bacterial and fungal isolates were identified by culture. Molecular bacterial profiling used next generation sequencing (NGS) of the 16S rRNA gene. Cultures grew bacteria and/or fungi in all CF gastric juice and sputa and in 9/14 non-CF gastric juices. Pseudomonas aeruginosa(Pa) was present in CF sputum in 11 patients, 4 had identical Pa strains in the stomach. NGS data from non-CF gastric juice samples were significantly more diverse compared to CF samples. NGS showed CF gastric juice had markedly lower abundance of normal gut bacteria; Bacteroides and Faecalibacterium, but increased Pseudomonas compared with non-CF. Multivariate partial least squares discriminant analysis demonstrated similar bacterial profiles of CF sputum and gastric juice samples, which were distinct from non-CF gastric juice. We provide novel evidence suggesting the existence of an aerodigestive microbiome in CF, which may have clinical relevance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.