Evidence map›Paper›PMID 27245217›Full record

ArticleScientific reports2016

Proteomic analysis of Plasmodium falciparum parasites from patients with cerebral and uncomplicated malaria.

Gwladys I Bertin, Audrey Sabbagh, Nicolas Argy, Virginie Salnot, Sem Ezinmegnon, Gino Agbota, Yélé Ladipo, Jules M Alao, Gratien Sagbo, François Guillonneau and 1 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

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  10. T cell-mediated immunity to malaria.Nature reviews. Immunology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Gwladys I BertinInstitut de Recherche pour le Développement (IRD), UMR216 - MERIT, Paris, France.
Audrey SabbaghInstitut de Recherche pour le Développement (IRD), UMR216 - MERIT, Paris, France.
Nicolas ArgyInstitut de Recherche pour le Développement (IRD), UMR216 - MERIT, Paris, France.
Virginie SalnotCOMUE Sorbonne Paris Cité, Faculté de Pharmacie de Paris, Paris Descartes University, Paris 75006, France.
Sem EzinmegnonCentre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et l'Enfance (CERPAGE), Cotonou, Benin.
Gino AgbotaInstitut de Recherche pour le Développement (IRD), UMR216 - MERIT, Paris, France.
Yélé LadipoPaediatric Department, Mother and child hospital (HOMEL), Cotonou, Benin.
Jules M AlaoPaediatric Department, Mother and child hospital (HOMEL), Cotonou, Benin.
Gratien SagboPaediatric Department, Centre National Hospitalo-Universitaire (CNHU), Cotonou, Benin.
François GuillonneauCOMUE Sorbonne Paris Cité, Faculté de Pharmacie de Paris, Paris Descartes University, Paris 75006, France.
Philippe DeloronInstitut de Recherche pour le Développement (IRD), UMR216 - MERIT, Paris, France.
Délégation Paris 5 · FRSorbonne Paris Cité · FRCentre National Hospitalier et Universitaire Hubert Koutoukou MAGA · BJInstitut de Recherche pour le Développement · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmodium falciparum is responsible of severe malaria, including cerebral malaria (CM). During its intra-erythrocytic maturation, parasite-derived proteins are expressed, exported and presented at the infected erythrocyte membrane. To identify new CM-specific parasite membrane proteins, we conducted a mass spectrometry-based proteomic study and compared the protein expression profiles between 9 CM and 10 uncomplicated malaria (UM) samples. Among the 1097 Plasmodium proteins identified, we focused on the 499 membrane-associated and hypothetical proteins for comparative analysis. Filter-based feature selection methods combined with supervised data analysis identified a subset of 29 proteins distinguishing CM and UM samples with high classification accuracy. A hierarchical clustering analysis of these 29 proteins based on the similarity of their expression profiles revealed two clusters of 15 and 14 proteins, respectively under- and over-expressed in CM. Among the over-expressed proteins, the MESA protein is expressed at the erythrocyte membrane, involved in proteins trafficking and in the export of variant surface antigens (VSAs), but without antigenic function. Antigen 332 protein is exported at the erythrocyte, also involved in protein trafficking and in VSAs export, and exposed to the immune system. Our proteomics data demonstrate an association of selected proteins in the pathophysiology of CM.

Indexed as

ProteomeAlgorithmsErythrocyte MembraneErythrocytesHumansMalaria, CerebralMalaria, FalciparumMembrane ProteinsPlasmodium falciparumPrincipal Component AnalysisProtozoan ProteinsTandem Mass SpectrometryTranscriptomeMembrane ProteinsProteomeProtozoan Proteins

Identifiers

PMID27245217
PMCPMC4887788
OpenAlexW2467757330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.