ArticleSchizophrenia bulletin2017
Traumatic Stress Disorders and Risk of Subsequent Schizophrenia Spectrum Disorder or Bipolar Disorder: A Nationwide Cohort Study.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The effectiveness and tolerability of trauma-focused psychotherapies for psychotic symptoms: A systematic review of trauma-focused psychotherapies.International journal of methods in psychiatric research · 2024Pooled it
- Longitudinal effects of lifetime trauma exposure and childhood sexual trauma by gender in individuals with first episode psychosis.The British journal of clinical psychology · 2026Article
- Psychological and psychosocial interventions for trauma-related psychological distress in adults living in ongoing conflict.The Cochrane database of systematic reviews · 2026Article
- State of the Science: The epidemiology of posttraumatic stress disorder.Journal of traumatic stress · 2026Review
- Dealing with Early-Onset Schizophrenia and the Role of Lurasidone: An Expert Opinion.Current neuropharmacology · 2026Review
- Associations among stress perception, clinical symptoms, and hippocampal subfield volumes in first-episode patients with schizophrenia.Frontiers in psychiatry · 2026Article
- Article
- Comparison of early risk factors between healthy siblings and subjects with schizophrenia and bipolar disorder.Frontiers in psychiatry · 2024Article
- Experience of traumatic events in people with severe mental illness in a low-income country: a qualitative study.International journal of mental health systems · 2023Article
- Diagnostic progression to schizophrenia in 35,255 patients with obsessive-compulsive disorder: a longitudinal follow-up study.European archives of psychiatry and clinical neuroscience · 2023Article
- Increased subsequent risk of mental disorders after experiencing stress-related disorders: correspondence.Annals of medicine and surgery (2012) · 2023Article
- Association of trauma, post-traumatic stress disorder and non-affective psychosis across the life course: a nationwide prospective cohort study.Psychological medicine · 2023Observational
- Case series: Cariprazine in early-onset schizophrenia.Frontiers in psychiatry · 2023Article
- Positive mental health framework of transdiagnostic protective factors in elucidating the association between adverse childhood experiences and severe mental disorders.The Australian and New Zealand journal of psychiatry · 2022Article
- Incidence rate of schizophrenia after the Tangshan earthquake in China: a 44-year retrospective birth cohort study.Translational psychiatry · 2022Article
- Trauma and psychosis: a qualitative study exploring the perspectives of people with psychosis on the influence of traumatic experiences on psychotic symptoms and quality of life.BMC psychiatry · 2022Article
- High incidence of PTSD diagnosis and trauma-related symptoms in a trauma exposed bipolar I and II sample.Frontiers in psychiatry · 2022Article
- The Greater Houston Area Bipolar Registry-Clinical and Neurobiological Trajectories of Children and Adolescents With Bipolar Disorders and High-Risk Unaffected Offspring.Frontiers in psychiatry · 2021Article
- Reconceptualizing Psychosis: The Hearing Voices Movement and Social Approaches to Health.Health and human rights · 2020Article
- Traumatic loss and psychosis - reconceptualising the role of trauma in psychosis.European journal of psychotraumatology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTraumatic stress disorders are prevalent in patients with schizophrenia and bipolar disorder. However, there is a lack of prospective longitudinal studies investigating the risk of severe mental illness for people diagnosed with traumatic stress disorders. We aimed to assess if patients with acute stress reaction (ASR) or post-traumatic stress disorder (PTSD) are at increased risk of schizophrenia spectrum disorders or bipolar disorder.
methodsWe performed a prospective cohort study covering the entire Danish population including information on inpatient and outpatient mental hospitals over 2 decades. Predictors were in- or outpatient diagnoses of ASR or PTSD. We calculated incidence rate ratios (IRR) with 95% CIs of schizophrenia, schizophrenia spectrum disorder, and bipolar disorder.
resultsPersons with a traumatic stress disorder had a significantly increased risk of schizophrenia (IRR 3.80, CI 2.33-5.80), schizophrenia spectrum disorder (IRR 2.34, CI 1.46-3.53), and bipolar disorder (IRR 4.22, CI 2.25-7.13). Risks were highest in the first year after diagnosis of the traumatic stress disorder and remained significantly elevated after more than 5 years. Mental illness in a parent could not explain the association.
conclusionOur findings support an association between diagnosed traumatic stress disorders and subsequent schizophrenia spectrum disorder or bipolar disorder. If replicated, this may increase clinical focus on patients with traumatic stress disorders.
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