Evidence map›Paper›PMID 27244893›Full record

ArticleOncotarget2017

Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma.

Cleo E Rolle, Yi-Hung Carol Tan, Tanguy Y Seiwert, Sapana Vora, Rajani Kanteti, Rifat Hasina, George B Carey, Mosmi Surati, Ralph R Weichselbaum, Mark W Lingen and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Cleo E RolleDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Yi-Hung Carol TanDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Tanguy Y SeiwertDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Sapana VoraDepartment of Pediatrics, The University of Chicago, Chicago, IL, USA.
Rajani KantetiDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Rifat HasinaDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
George B CareyDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Mosmi SuratiPritzker School of Medicine, The University of Chicago, Chicago, IL, USA.
Ralph R WeichselbaumDepartment of Radiation and Cellular Oncology/Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, USA.
Mark W LingenDepartment of Pathology, The University of Chicago, Chicago, IL, USA.
Everett E VokesDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Ravi SalgiaDepartment of Medical Oncology and Therapeutic Research, City of Hope, Duarte, CA, USA.
University of Chicago · USCity of Hope · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MET is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and degraded by c-CBL E3-ubiquitin ligase. We investigated genetic variations of c-CBL in HNSCC and the relationship between c-CBL and MET expression. High MET, low c-CBL expression was detected in 10 cell lines and 73 tumor tissues. Two novel mutations (L254S, L281F), and the single nucleotide polymorphism (SNP) P782L were identified from archival tumor tissues. 27.3% of loss of heterozygosity was found at CBL locus. Ectopic expression of wild-type c-CBL in SCC-35 cells downregulated MET expression and decreased cell viability. These results suggest MET overexpression is related to altered c-CBL expression, which may influence tumorigenesis.

Indexed as

Carcinoma, Squamous CellDNA Mutational AnalysisGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansImmunoblottingImmunohistochemistryLoss of HeterozygosityProto-Oncogene Proteins c-cblProto-Oncogene Proteins c-metSquamous Cell Carcinoma of Head and NeckTissue Array AnalysisCBL protein, humanMET protein, humanProto-Oncogene Proteins c-cblProto-Oncogene Proteins c-metc-CBLhead and neck cancerMET

Identifiers

PMID27244893
PMCPMC5386642
OpenAlexW2395655065

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.