Evidence map›Paper›PMID 27244842›Full record

ArticlePediatrics2016

Presumed Pseudotumor Cerebri Syndrome After Withdrawal of Inhaled Glucocorticoids.

Young Joon Kwon, Julian L Allen, Grant T Liu, Shana E McCormack

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Visual outcomes of idiopathic intracranial hypertension in a neuro-ophthalmology clinic in Jeddah, Saudi Arabia.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Young Joon KwonDivisions of Human Genetics.
Julian L AllenPulmonary Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Grant T LiuPerelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Ophthalmology, Neuro-ophthalmology Service, and.
Shana E McCormackPerelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and mccormacks1@email.chop.edu.
Children's Hospital of Philadelphia · USPulmonary Associates · USUniversity of Pennsylvania · US

Funding

Career Development Program in Pediatric Diabetes Research (K12) at CHOPK12DK094723 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WILLI, STEVEN M · 2011 to 2020
$3.6M
Translational investigation of abnormal fat metabolism in mitochondrial diseaseK23DK102659 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI MCCORMACK, SHANA ERIN · 2015 to 2017
$515k
NIDDK NIH HHS K12 DK094723NIDDK NIH HHS K23 DK102659
6 · The paper itself

Abstract

Pseudotumor cerebri syndrome (PTCS) is characterized by increased intracranial pressure with normal brain parenchyma and cerebrospinal fluid constituents. PTCS after withdrawal of systemic corticosteroids also has been described in children. In contrast, to our knowledge, PTCS after withdrawal of inhaled glucocorticoids has not previously been described. Here we report the case of an 8-year and 6-month-old girl who developed signs and symptoms consistent with PTCS after withdrawal of inhaled glucocorticoids. The patient had excellent adherence to inhaled glucocorticoid therapy for ∼1 year before presentation, after which the therapy was stopped for concern related to poor growth. The withdrawal of inhaled glucocorticoids was associated with the development of severe headaches and diplopia, and further clinical examination led to the patient's diagnosis of likely PTCS. Although its occurrence is likely rare, clinicians caring for the many children receiving inhaled glucocorticoid therapy should be aware of the potential for PTCS after abrupt withdrawal of such treatment, and consider ophthalmology evaluation if patients report suggestive symptoms, such as headaches or vision changes in this context.

Indexed as

AcetazolamideAdministration, InhalationAsthmaChildDiplopiaFemaleGlucocorticoidsGrowthHeadacheHumansPseudotumor CerebriWithholding TreatmentAcetazolamideGlucocorticoids

Identifiers

PMID27244842
PMCPMC4894252
OpenAlexW2399220242

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.