Trial reportPediatrics2016
Cognitive Behavioral Therapy in Primary Care for Youth Declining Antidepressants: A Randomized Trial.
Trial report in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparative Effects of Various Modalities of Cognitive Behavioral Therapy for Insomnia in Adolescents: A Systematic Review and Network Meta-Analysis.Worldviews on evidence-based nursing · 2026Pooled it
- Next-Generation Cognitive-Behavioral Therapy for Depression: Integrating Digital Tools, Teletherapy, and Personalization for Enhanced Mental Health Outcomes.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Cognitive behavioral therapy for primary care depression and anxiety: a secondary meta-analytic review using robust variance estimation in meta-regression.Journal of behavioral medicine · 2019Pooled it
- Psychological and Behavioral Issues in the Management of Migraine in Children and Adolescents.Current pain and headache reports · 2016Pooled it
- Preliminary Efficacy of a Digital Intervention for Adolescent Depression: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Cost-effectiveness of Cognitive Behavioral Therapy for Depressed Youth Declining Antidepressants.Pediatrics · 2018Trial
- The effects of group nursing intervention based on emotion regulation training on depression and nonsuicidal self-injury in adolescents.BMC psychology · 2025Article
- A comparison of the effectiveness of cognitive behavioural interventions based on delivery features for elevated symptoms of depression in adolescents: A systematic review.Campbell systematic reviews · 2024Review
- A CBT-based mobile intervention as an adjunct treatment for adolescents with symptoms of depression: a virtual randomized controlled feasibility trial.Frontiers in digital health · 2023Article
- Psychological Treatments for Depression in Adolescents: More Than Three Decades Later.International journal of environmental research and public health · 2021Review
- Cognitive behavioral therapy combined with "empathy nursing" model on recurrent depressive disorder.American journal of translational research · 2021Article
- Increases in Suicide Deaths Among Adolescents and Young Adults Following US Food and Drug Administration Antidepressant Boxed Warnings and Declines in Depression Care.Psychiatric research and clinical practice · 2020Article
- Primary outcome reporting in adolescent depression clinical trials needs standardization.BMC medical research methodology · 2020Article
- Beyond the trigger: The mental health consequences of in-home firearm access among children of gun owners.Social science & medicine (1982) · 2018Article
- Evidence on the longitudinal construct validity of major generic and utility measures of health-related quality of life in teens with depression.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review.Journal of primary care & community healthArticle
- Supporting Quality Integrated Care for Adolescent Depression in Primary Care: A Learning System Approach.International journal of integrated careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectiveHealth care providers have few alternatives for youth depression other than antidepressants. We examined whether brief cognitive behavioral therapy (CBT) is a viable alternative in primary care.
methodsA total of 212 adolescents aged 12 to 18 with major depression who had recently declined or quickly discontinued new antidepressant treatment were randomized to self-selected treatment as usual (TAU) control condition or TAU plus brief individual CBT. Blinded evaluators followed youth for 2 years. The primary outcome was time to major depression diagnostic recovery.
resultsCBT was superior to the control condition on the primary outcome of time to diagnostic recovery from major depression, with number needed to treat from 4 to 10 across follow-up. A similar CBT advantage was found for time to depression diagnosis response, with number needed to treat of 5 to 50 across time points. We observed a significant advantage for CBT on many secondary outcomes over the first year of follow-up but not the second year. Cohen's d effect sizes for significant continuous measures ranged from 0.28 to 0.44, in the small to medium effect range. Most TAU health care services did not differ across conditions, except for psychiatric hospitalizations, which occurred at a significantly higher rate in the control condition through the first year of follow-up.
conclusionsObserved results were consistent with recent meta-analyses of CBT for youth depression. The initial year of CBT superiority imparted an important clinical benefit and may reduce the risk of future recurrent depression episodes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.