Evidence map›Paper›PMID 27244776›Full record

ReviewPediatrics2016

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation.

Nandini Vijayakanthi, John M Greally, Deepa Rastogi

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Asthma heterogeneity among Asian American children: The California Health Interview Survey.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Persistent overweight or obesity, lung function, and asthma exacerbations in Puerto Rican youth.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Article
  14. Review
  15. An Overview of the Obese-Asthma Phenotype in Children.International journal of environmental research and public health · 2022
    Review
  16. Article
  17. Article
  18. Dynamic Metabolic Risk Profiling of World Trade Center Lung Disease: A Longitudinal Cohort Study.American journal of respiratory and critical care medicine · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nandini VijayakanthiDepartments of Pediatrics.
John M GreallyDepartments of Pediatrics, Genetics, and Medicine, Albert Einstein College of Medicine, Bronx, New York.
Deepa RastogiDepartments of Pediatrics, drastogi@montefiore.org.
Pediatrics and Genetics · USAlbert Einstein College of Medicine · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
In vivo imaging of X inactivationR01DA030317 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GREALLY, JOHN, LEVY, MATTHEW · 2010 to 2014
$3.0M
Genetic and Epigenetic Determinants of Pediatric Obesity-Associated AsthmaK23HL118733 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RASTOGI, DEEPA · 2014 to 2018
$893k
Mapping and Functional Analysis of RNA:DNA Hybrid-Forming LociR21GM101880 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GREALLY, JOHN · 2012 to 2013
$452k
NCATS NIH HHS UL1 TR001073NCI NIH HHS P30 CA013330NHLBI NIH HHS K23 HL118733NIDA NIH HHS R01 DA030317NIDDK NIH HHS P30 DK020541NIGMS NIH HHS R21 GM101880
6 · The paper itself

Abstract

The burden of obesity-related asthma among children, particularly among ethnic minorities, necessitates an improved understanding of the underlying disease mechanisms. Although obesity is an independent risk factor for asthma, not all obese children develop asthma. Several recent studies have elucidated mechanisms, including the role of diet, sedentary lifestyle, mechanical fat load, and adiposity-mediated inflammation that may underlie the obese asthma pathophysiology. Here, we review these recent studies and emerging scientific evidence that suggest metabolic dysregulation may play a role in pediatric obesity-related asthma. We also review the genetic and epigenetic factors that may underlie susceptibility to metabolic dysregulation and associated pulmonary morbidity among children. Lastly, we identify knowledge gaps that need further exploration to better define pathways that will allow development of primary preventive strategies for obesity-related asthma in children.

Indexed as

AsthmaChildDietEpigenesis, GeneticHumansInsulinPediatric ObesityInsulin

Identifiers

PMID27244776
PMCPMC4845863
OpenAlexW2321313850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.