ArticleIEEE transactions on bio-medical engineering2017
Intratidal Overdistention and Derecruitment in the Injured Lung: A Simulation Study.
Article in IEEE transactions on bio-medical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography.Intensive care medicine experimental · 2026Review
- Structural and functional characteristics of healthy and injured porcine lungs during deflation: a quantitative CT imaging analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation.Respiratory care · 2024Article
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- Quantifying Regional Lung Deformation Using Four-Dimensional Computed Tomography: A Comparison of Conventional and Oscillatory Ventilation.Frontiers in physiology · 2020Article
- Reactance and elastance as measures of small airways response to bronchodilator in asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation.International journal for numerical methods in biomedical engineering · 2019Article
- Computational Modeling of Primary Blast Lung Injury: Implications for Ventilator Management.Military medicine · 2019Article
- Article
- Parenchymal strain heterogeneity during oscillatory ventilation: why two frequencies are better than one.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Regional gas transport in the heterogeneous lung during oscillatory ventilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
goalVentilated patients with the acute respiratory distress syndrome (ARDS) are predisposed to cyclic parenchymal overdistention and derecruitment, which may worsen existing injury. We hypothesized that intratidal variations in global mechanics, as assessed at the airway opening, would reflect such distributed processes.
methodsWe developed a computational lung model for determining local instantaneous pressure distributions and mechanical impedances continuously during a breath. Based on these distributions and previous literature, we simulated the within-breath variability of airway segment dimensions, parenchymal viscoelasticity, and acinar recruitment in an injured canine lung for tidal volumes( V
resultsFor conditions of low V
conclusionIntratidal variations in lung mechanics may allow for optimization of ventilator settings in patients with ARDS, by balancing lung recruitment against parenchymal overdistention. SIGNIFICANCE: Titration of airway pressures based on variations in intratidal mechanics may mitigate processes associated with injurious ventilation.
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