ArticleScientific reports2016
Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Mycelial morphology influenced aerobic DNRA inMicrobiology spectrum · 2026Article
- Microbial transglutaminase in food biotechnology: from biochemical mechanisms to industrial applications.Applied microbiology and biotechnology · 2026Review
- Essential and dispensable domains of DivIVA for walled growth in filamentous Actinomycetota.Open biology · 2025Article
- Engineering bacterial cell morphology for the design of robust cell factories.Biochemistry and biophysics reports · 2025Review
- Morphology-engineered alleviation of mycelial aggregation inSynthetic and systems biotechnology · 2025Article
- Adjusting Aspergillus niger pellet diameter, population heterogeneity, and core architecture during shake flask cultivation.Biotechnology for biofuels and bioproducts · 2025Article
- Method for evaluation of Streptomyces growth and metabolism in the presence of glyphosate-based herbicide.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Contractile injection systems facilitate sporogenic differentiation of Streptomyces davawensis through the action of a phage tapemeasure protein-related effector.Nature communications · 2024Article
- Endocytosis-like DNA uptake by cell wall-deficient bacteria.Nature communications · 2022Article
- Generating Heterokaryotic Cells via Bacterial Cell-Cell Fusion.Microbiology spectrum · 2022Article
- Role for a Lytic Polysaccharide Monooxygenase in Cell Wall Remodeling in Streptomyces coelicolor.mBio · 2022Article
- Reviewing a plethora of oxidative-type reactions catalyzed by whole cells ofRSC advances · 2022Review
- An Alternative and Conserved Cell Wall Enzyme That Can Substitute for the Lipid II Synthase MurG.mBio · 2021Article
- Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides.PLoS biology · 2020Article
- Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium.Communications biology · 2020Article
- A Novel Two-Component System, Encoded by the sFrontiers in microbiology · 2019Article
- Streptomyces Differentiation in Liquid Cultures as a Trigger of Secondary Metabolism.Antibiotics (Basel, Switzerland) · 2018Review
- Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD.Scientific reports · 2018Article
- Microencapsulation extends mycelial viability of Streptomyces lividans 66 and increases enzyme production.BMC biotechnology · 2018Article
- Morphology-driven downscaling of Streptomyces lividans to micro-cultivation.Antonie van Leeuwenhoek · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomycetes are filamentous bacteria that produce numerous valuable compounds, including the majority of clinically used antibiotics. At an industrial scale, most of these compounds are produced in bioreactors. Growth of streptomycetes under these conditions is characterized by the formation of complex mycelial particles, whose sizes follow a bimodal distribution. Given the correlation between specific productivity and morphology, this size heterogeneity poses a potential drawback in industry. Recent work indicates that mycelial morphology is controlled by a number of genes that encode proteins required for the synthesis of cell surface-associated glycans. Using a quantifiable system based on fluorescent markers, we here show that these glycans mediate aggregation between germlings and young mycelia, yielding mycelial particles that originate from many different individuals. We also demonstrate that at later time points aggregation between distinct particles is no longer detectable. Notably, the absence of the corresponding glycan synthases yields mycelia that are homogeneous in size, identifying mycelial aggregation as a driving factor towards size heterogeneity. Given that aggregation is widespread within streptomycetes and can also occur between different Streptomyces strains, our work paves the way to improve Streptomyces as a cell factory for the production of known metabolites, but possibly also to discover new ones.
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