SynthesisNature communications2016
Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Meta-Analysis of Genetic Variants Associated With HBV Infection Susceptibility and Hepatocellular Carcinoma Risk.Journal of viral hepatitis · 2026Pooled it
- Association between IL28B Polymorphisms and Outcomes of Hepatitis B Virus Infection: A meta-analysis.BMC medical genetics · 2020Pooled it
- Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese.Scientific reports · 2017Trial
- Coxsackievirus B3 Cleaves INTS10 Through 3C Protease to Facilitate Its Replication.International journal of molecular sciences · 2026Article
- Impact of TNF-α (- 308G>A and - 857 C>T) promoter variants on susceptibility to chronic hepatitis B virus infection in a cohort of Mauritanian patients: pilot study.BMC microbiology · 2026Article
- Article
- Expression and significance of INTS10 and IRF3 in chronic hepatitis B patients.Frontiers in microbiology · 2025Article
- Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes.Arthritis research & therapy · 2023Article
- An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation.EBioMedicine · 2023Article
- A functional variant of CD40 modulates clearance of hepatitis B virus in hepatocytes via regulation of the ANXA2/CD40/BST2 axis.Human molecular genetics · 2023Article
- Conventional and genetic risk factors for chronic Hepatitis B virus infection in a community-based study of 0.5 million Chinese adults.Scientific reports · 2022Article
- Innate and adaptive immune escape mechanisms of hepatitis B virus.World journal of gastroenterology · 2022Review
- Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.Frontiers in genetics · 2022Article
- Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families.World journal of gastroenterology · 2021Article
- Viral hepatitis update: Progress and perspectives.World journal of gastroenterology · 2021Review
- Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression.BMC medical genomics · 2021Article
- Host genetics and infectious disease: new tools, insights and translational opportunities.Nature reviews. Genetics · 2021Review
- Article
- A Novel Prognostic Model for Oral Squamous Cell Carcinoma: The Functions and Prognostic Values of RNA-Binding Proteins.Frontiers in oncology · 2021Article
- Genome-wide association study identifies 7q11.22 and 7q36.3 associated with noise-induced hearing loss among Chinese population.Journal of cellular and molecular medicine · 2021Article
Corrections and comments
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Authors and funding
50 authors at 13 institutions in 1 country.
Yuanfeng LiState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Lanlan SiState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yun ZhaiState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yanling HuCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
Zhibin HuDepartment of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Jin-Xin BeiState Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
Bobo XieState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Qian RenState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Pengbo CaoState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Fei YangState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Qingfeng SongAffiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Zhiyu BaoAffiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Haitao ZhangState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yuqing HanState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Zhifu WangState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xi ChenState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xia XiaState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Hongbo YanState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Rui WangState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Ying ZhangState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Chengming GaoState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Jinfeng MengState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xinyi TuState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xinqiang LiangAffiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Ying CuiAffiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Ying LiuNational Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China.
Xiaopan WuNational Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China.
Zhuo LiDepartment of Infectious Disease, Affiliated You'an Hospital, Capital University of Medical Science, Beijing 100069, China.
Huifen WangLiver Failure Treatment and Research Center, Beijing 302 Hospital, Beijing 100039, China.
Zhaoxia LiDepartment of Clinical Laboratory, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Bo HuDepartment of Clinical Laboratory, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Minghui HeBGI-Shenzhen, Shenzhen 518031, China.
Zhibo GaoBGI-Shenzhen, Shenzhen 518031, China.
Xiaobing XuDepartment of Gastroenterology and Hepatology, Jinling Hospital, Clinical School of Nanjing University, Nanjing 210002, China.
Hongzan JiDepartment of Gastroenterology and Hepatology, Jinling Hospital, Clinical School of Nanjing University, Nanjing 210002, China.
Chaohui YuDepartment of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Yi SunDepartment of Hepatobiliary Surgery I, Peking University Cancer Hospital and Institute, Beijing 100142, China.
Baocai XingDepartment of Hepatobiliary Surgery I, Peking University Cancer Hospital and Institute, Beijing 100142, China.
Xiaobo YangCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
Haiying ZhangCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
Aihua TanCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
Chunlei WuCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
Weihua JiaState Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
Shengping LiState Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
Yi-Xin ZengState Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
Hongbing ShenDepartment of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Fuchu HeState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Zengnan MoCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
Hongxing ZhangState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Gangqiao ZhouState Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Beijing Proteome Research Center · CNGuangxi Medical University · CNSouthern Medical University · CNBGI Group (China) · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNNanjing Medical University · CNPeking University · CNThird Affiliated Hospital of Sun Yat-sen University · CN302 Military Hospital of China · CNBeijing YouAn Hospital · CNNanjing General Hospital of Nanjing Military Command · CNNanjing University · CNZhejiang University · CN
Funding
Southern HIV and Alcohol Research Consortium Administrative and Research Support CoreU24AA022002 · NIAAA · UNIVERSITY OF FLORIDA · PI COOK, ROBERT L · 2012 to 2022
$5.5MNIAAA NIH HHS U24 AA022002
Abstract
Hepatitis B virus (HBV) infection is a common infectious disease. Here we perform a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci involved in persistent HBV infection. GWAS scan is performed in 1,251 persistently HBV infected subjects (PIs, cases) and 1,057 spontaneously recovered subjects (SRs, controls), followed by replications in four independent populations totally consisting of 3,905 PIs and 3,356 SRs. We identify a novel locus at 8p21.3 (index rs7000921, odds ratio=0.78, P=3.2 × 10(-12)). Furthermore, we identify significant expression quantitative trait locus associations for INTS10 gene at 8p21.3. We demonstrate that INST10 suppresses HBV replication via IRF3 in liver cells. In clinical plasma samples, we confirm that INST10 levels are significantly decreased in PIs compared with SRs, and negatively correlated with the HBV load. These findings highlight a novel antiviral gene INTS10 at 8p21.3 in the clearance of HBV infection.
Indexed as
Genetic Predisposition to DiseaseAdultAgedAsian PeopleCarrier ProteinsCase-Control StudiesCell LineChromosomes, Human, Pair 8FemaleGenetic LociGenome-Wide Association StudyHepatitis B, ChronicHepatitis B Surface AntigensHepatitis B virusHepatocytesHumansCarrier ProteinsHepatitis B Surface AntigensInterferon Regulatory Factor-3INTS10 protein, humanIRF3 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.