ArticleJournal of the American Chemical Society2016
Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- The Paradox of Antimalarial Terpenoid Isonitrile Biosynthesis Explained. Proposal of Cyanoformate as an NC Delivery Vector.Journal of natural products · 2025Article
- Repositioning Brusatol as a Transmission Blocker of Malaria Parasites.ACS infectious diseases · 2024Article
- A kalihinol analog disrupts apicoplast function and vesicular trafficking inScience (New York, N.Y.) · 2024Article
- Heavy Heterodendralenes: Structure and Reactivity of Phosphabora[3]dendralenes.Journal of the American Chemical Society · 2024Article
- Unified Synthesis of 2-Isocyanoallopupukeanane and 9-Isocyanopupukeanane through a "Contra-biosynthetic" Rearrangement.Angewandte Chemie (International ed. in English) · 2024Article
- Highly Diastereoselective Preparation of Tertiary Alkyl Isonitriles by Stereoinvertive Nucleophilic Substitution at a Nonclassical Carbocation.Organic letters · 2023Article
- An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure.Journal of the American Chemical Society · 2023Article
- Enantioselective oxa-Diels-Alder Sequences of Dendralenes.Angewandte Chemie (International ed. in English) · 2022Article
- Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane.The Journal of organic chemistry · 2022Article
- Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022Article
- Natural Product Synthesis through the Lens of Informatics.Accounts of chemical research · 2021Review
- Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites.Bioorganic & medicinal chemistry · 2020Article
- Total syntheses of spiroviolene and spirograterpene A: a structural reassignment with biosynthetic implications.Chemical science · 2020Article
- Nucleophilic Isocyanation.ACS omega · 2020Review
- A general synthesis of dendralenes.Chemical science · 2019Article
- Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20-Diisocyanoadociane.Angewandte Chemie (International ed. in English) · 2019Article
- The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer.Accounts of chemical research · 2018Article
- Acetylene in Organic Synthesis: Recent Progress and New Uses.Molecules (Basel, Switzerland) · 2018Review
- Stereocontrolled Synthesis of Kalihinol C.Journal of the American Chemical Society · 2017Article
- Antimalarial Properties of Simplified Kalihinol Analogues.ACS medicinal chemistry letters · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
7,20-Diisocyanoadociane, a scarce marine metabolite with potent antimalarial activity, was synthesized as a single enantiomer in 13 steps from simple building blocks (17 linear steps). Chemical synthesis enabled identification of isocyanoterpene antiplasmodial activity against liver-stage parasites, which suggested that inhibition of heme detoxification does not exclusively underlie the mechanism of action of this class.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.