ArticleAnalytical chemistry2016
A Paper-Based "Pop-up" Electrochemical Device for Analysis of Beta-Hydroxybutyrate.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 176 citations in OpenAlex.
- Review
- Paper as a Sustainable Material for Smart Electrochemical (Bio)sensors with Unprecedented Features: A Perspective.Analytical chemistry · 2025Review
- Tandem metabolic reaction-based sensors unlock in vivo metabolomics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recent Advances in the Fabrication and Application of Electrochemical Paper-Based Analytical Devices.Biosensors · 2024Review
- Development of a disposable paper-based thin film solid-phase microextraction sampling kit to quantify ketone body.RSC advances · 2024Article
- Electrochemical detection of poly(3-hydroxybutyrate) production from Burkholderia glumae MA13 using a molecularly imprinted polymer-reduced graphene oxide modified electrode.Mikrochimica acta · 2024Article
- Sample preparation and detection methods in point-of-care devices towards future at-home testing.Lab on a chip · 2024Review
- Paper-Based Enzymatic Electrochemical Sensors for Glucose Determination.Sensors (Basel, Switzerland) · 2022Review
- Recent Developments in Microfluidic Paper-based Analytical Devices for Pharmaceutical Analysis.Current topics in medicinal chemistry · 2022Article
- Low-cost and cleanroom-free prototyping of microfluidic and electrochemical biosensors: Techniques in fabrication and bioconjugation.Biomicrofluidics · 2021Review
- Origami Paper-Based Electrochemical (Bio)Sensors: State of the Art and Perspective.Biosensors · 2021Review
- Development of an Integrated Optical Sensor for Determination of β-Hydroxybutyrate Within the Microplatform.Applied biochemistry and biotechnology · 2021Article
- Laser engraved microapillary pump paper-based microfluidic device for colorimetric and electrochemical detection of salivary thiocyanate.Mikrochimica acta · 2021Article
- Triboelectric Effect Enabled Self-Powered, Point-of-Care Diagnostics: Opportunities for Developing ASSURED and REASSURED Devices.Micromachines · 2021Review
- Paper-Based Screen-Printed Electrodes: A New Generation of Low-Cost Electroanalytical Platforms.Biosensors · 2021Review
- Dry storage of multiple reagent types within a paper microfluidic device for phenylalanine monitoring.Analytical methods : advancing methods and applications · 2021Article
- Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor.Sensors (Basel, Switzerland) · 2020Review
- Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays.Micromachines · 2020Review
- Recent Developments of Flexible and Stretchable Electrochemical Biosensors.Micromachines · 2020Review
- Electrochemical Paper-Based Biosensor Devices for Rapid Detection of Biomarkers.Sensors (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
This paper describes the design and fabrication of a "pop-up" electrochemical paper-based analytical device (pop-up-EPAD) to measure beta-hydroxybutyrate (BHB)-a biomarker for diabetic ketoacidosis-using a commercial combination BHB/glucometer. Pop-up-EPADs are inspired by pop-up greeting cards and children's books. They are made from a single sheet of paper folded into a three-dimensional (3D) device that changes shape, and fluidic and electrical connectivity, by simply folding and unfolding the structure. The reconfigurable 3D structure makes it possible to change the fluidic path and to control timing; it also provides mechanical support for the folded and unfolded structures that enables good registration and repeatability on folding. A pop-up-EPAD designed to detect BHB shows performance comparable to commercially available plastic test strips over the clinically relevant range of BHB in blood when used with a commercial glucometer that integrates the ability to measure glucose and BHB (combination BHB/glucometer). With simple modifications of the electrode and the design of the fluidic path, the pop-up-EPAD also detects BHB in buffer using a simple glucometer-a device that is more available than the combination BHB/glucometer. Strategies that use a "3D pop-up"-that is, large-scale changes in 3D structure and fluidic paths-by folding/unfolding add functionality to EPADs (e.g., controlled timing, fluidic handling and path programming, control over complex sequences of steps, and alterations in electrical connectivity) and should enable the development of new classes of paper-based diagnostic devices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.