ArticleScientific reports2016
A Phytophthora sojae effector PsCRN63 forms homo-/hetero-dimers to suppress plant immunity via an inverted association manner.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 53 citations in OpenAlex.
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- Adaptive Defense Mechanism During Flowering Period ofPlants (Basel, Switzerland) · 2025Article
- Identification of Phytophthora cinnamomi CRN effectors and their roles in manipulating cell death during Persea americana infection.BMC genomics · 2024Article
- The PTI-suppressing Avr2 effector from Fusarium oxysporum suppresses mono-ubiquitination and plasma membrane dissociation of BIK1.Molecular plant pathology · 2023Article
- Fungal Effectoromics: A World in Constant Evolution.International journal of molecular sciences · 2022Review
- The heterologous expression of conserved Glycine max (soybean) mitogen activated protein kinase 3 (MAPK3) paralogs suppresses Meloidogyne incognita parasitism in Gossypium hirsutum (upland cotton).Transgenic research · 2022Article
- Pathogen effectors: What do they do at plasmodesmata?Molecular plant pathology · 2022Review
- Unraveling Plant Cell Death duringMicroorganisms · 2022Review
- Two stripe rust effectors impair wheat resistance by suppressing import of host Fe-S protein into chloroplasts.Plant physiology · 2021Article
- Perturbations in nitric oxide homeostasis promote Arabidopsis disease susceptibility towards Phytophthora parasitica.Molecular plant pathology · 2021Article
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- AFrontiers in plant science · 2021Article
- A LysM Domain-Containing Protein LtLysM1 Is Important for Vegetative Growth and Pathogenesis in Woody Plant PathogenThe plant pathology journal · 2020Article
- Organize, Don't Agonize: Strategic Success ofMicroorganisms · 2020Review
- A Phytophthora capsici effector suppresses plant immunity via interaction with EDS1.Molecular plant pathology · 2020Article
- The PTI to ETI Continuum inFrontiers in plant science · 2020Review
- Effectors of Phytophthora pathogens are powerful weapons for manipulating host immunity.Planta · 2019Review
- Plasmopara viticola effector PvRXLR131 suppresses plant immunity by targeting plant receptor-like kinase inhibitor BKI1.Molecular plant pathology · 2019Article
- Systematic Y2H Screening Reveals Extensive Effector-Complex Formation.Frontiers in plant science · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oomycete pathogens produce a large number of effectors to promote infection. Their mode of action are largely unknown. Here we show that a Phytophthora sojae effector, PsCRN63, suppresses flg22-induced expression of FRK1 gene, a molecular marker in pathogen-associated molecular patterns (PAMP)-triggered immunity (PTI). However, PsCRN63 does not suppress upstream signaling events including flg22-induced MAPK activation and BIK1 phosphorylation, indicating that it acts downstream of MAPK cascades. The PsCRN63-transgenic Arabidopsis plants showed increased susceptibility to bacterial pathogen Pseudomonas syringae pathovar tomato (Pst) DC3000 and oomycete pathogen Phytophthora capsici. The callose deposition were suppressed in PsCRN63-transgenic plants compared with the wild-type control plants. Genes involved in PTI were also down-regulated in PsCRN63-transgenic plants. Interestingly, we found that PsCRN63 forms an dimer that is mediated by inter-molecular interactions between N-terminal and C-terminal domains in an inverted association manner. Furthermore, the N-terminal and C-terminal domains required for the dimerization are widely conserved among CRN effectors, suggesting that homo-/hetero-dimerization of Phytophthora CRN effectors is required to exert biological functions. Indeed, the dimerization was required for PTI suppression and cell death-induction activities of PsCRN63.
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