ArticleFrontiers in bioengineering and biotechnology2016
Human Mesenchymal Stem Cell Morphology and Migration on Microtextured Titanium.
Article in Frontiers in bioengineering and biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05182489 (Lumbar Fusion With Micro and Nano-textured Titanium Interbody Cages - A Single-Blinded Randomized Controlled Trial Evaluating Adaptix™ Versus PEEK Cages), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lumbar Fusion With Micro and Nano-textured Titanium Interbody Cages - A Single-Blinded Randomized Controlled Trial Evaluating Adaptix™ Versus PEEK Cages
Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing.British journal of cancer · 2026Article
- Stand-alone porous titanium cages for anterior cervical discectomy and fusion: clinical outcomes in a multicenter experience.Neurosurgical review · 2026Observational
- Transient biological response of human mesenchymal stem cells to a single wideband high-power electromagnetic pulse exposure: a preliminary study.Frontiers in cell and developmental biology · 2026Article
- Porous 3D Printed Titanium Cages in Anterior Cervical Discectomy and Fusion are Associated With Less Subsidence, Improved Maintenance of Segmental Lordotic Correction, and Similar Clinical Outcomes as Allograft.Global spine journal · 2024Article
- Nanoscale Modification of Titanium Implants Improves Behaviors of Bone Mesenchymal Stem Cells and OsteogenesisOxidative medicine and cellular longevity · 2022Article
- Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity.Integrative biology : quantitative biosciences from nano to macro · 2021Article
- Can activated titanium interbody cages accelerate or enhance spinal fusion? a review of the literature and a design for clinical trials.Journal of materials science. Materials in medicine · 2021Review
- Biophysical phenotyping of mesenchymal stem cells along the osteogenic differentiation pathway.Cell biology and toxicology · 2021Review
- Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium.Bioactive materials · 2019Article
- Human dental pulp stem cell adhesion and detachment in polycaprolactone electrospun scaffolds under direct perfusion.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Repositioning Titanium: AnFrontiers in bioengineering and biotechnology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The implant used in spinal fusion procedures is an essential component to achieving successful arthrodesis. At the cellular level, the implant impacts healing and fusion through a series of steps: first, mesenchymal stem cells (MSCs) need to adhere and proliferate to cover the implant; second, the MSCs must differentiate into osteoblasts; third, the osteoid matrix produced by the osteoblasts needs to generate new bone tissue, thoroughly integrating the implant with the vertebrate above and below. Previous research has demonstrated that microtextured titanium is advantageous over smooth titanium and PEEK implants for both promoting osteogenic differentiation and integrating with host bone tissue; however, no investigation to date has examined the early morphology and migration of MSCs on these surfaces. This study details cell spreading and morphology changes over 24 h, rate and directionality of migration 6-18 h post-seeding, differentiation markers at 10 days, and the long-term morphology of MSCs at 7 days, on microtextured, acid-etched titanium (endoskeleton), smooth titanium, and smooth PEEK surfaces. The results demonstrate that in all metrics, the two titanium surfaces outperformed the PEEK surface. Furthermore, the rough acid-etched titanium surface presented the most favorable overall results, demonstrating the random migration needed to efficiently cover a surface in addition to morphologies consistent with osteoblasts and preosteoblasts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.