ArticleFrontiers in microbiology2016
New Insights into the Genetic Diversity of Clostridium botulinum Group III through Extensive Genome Exploration.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Animal Botulism in Poland - Laboratory and Epidemiological Investigations.Journal of veterinary research · 2022Article
- Extensive Genome Exploration ofMicroorganisms · 2021Article
- Exploration of the Diversity of Clustered Regularly Interspaced Short Palindromic Repeats-Cas Systems inFrontiers in microbiology · 2021Article
- Endogenous CRISPR-Cas Systems in Group IFrontiers in microbiology · 2021Article
- Review
- Review
- Genomics of the Pathogenic Clostridia.Microbiology spectrum · 2019Review
- Substrate cleavage and duration of action of botulinum neurotoxin type FA ("H, HA").Toxicon : official journal of the International Society on Toxinology · 2018Article
- Review
- Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance.Frontiers in bioengineering and biotechnology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal botulism is caused by group III Clostridium botulinum strains producing type C and D toxins, or their chimeric forms C/D and D/C. Animal botulism is considered an emerging disease in Europe, notably in poultry production. Before our study, 14 genomes from different countries were available in the public database, but none were from France. In order to investigate the genetic relationship of French strains with different geographical areas and find new potential typing targets, 17 strains of C. botulinum group III were sequenced (16 from France and one from New Caledonia). Fourteen were type C/D strains isolated from chickens, ducks, guinea fowl and turkeys and three were type D/C strains isolated from cattle. The New Caledonian strain was a type D/C strain. Whole genome sequence analysis showed the French strains to be closely related to European strains from C. botulinum group III lineages Ia and Ib. The investigation of CRISPR sequences as genetic targets for differentiating strains in group III proved to be irrelevant for type C/D due to a deficient CRISPR/Cas mechanism, but not for type D/C. Conversely, the extrachromosomal elements of type C/D strains could be used to generate a genetic ID card. The highest level of discrimination was achieved with SNP core phylogeny, which allowed differentiation up to strain level and provide the most relevant information for genetic epidemiology studies and discrimination.
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Registered trials
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