Evidence map›Paper›PMID 27242760›Full record

ReviewFrontiers in microbiology2016

Drug Resistance Mechanisms in Bacteria Causing Sexually Transmitted Diseases and Associated with Vaginosis.

Boris Shaskolskiy, Ekaterina Dementieva, Arvo Leinsoo, Anastassia Runina, Denis Vorobyev, Xenia Plakhova, Alexey Kubanov, Dmitrii Deryabin, Dmitry Gryadunov

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Life (Basel, Switzerland) · 2023
    Review
  4. Observational
  5. Review
  6. Article
  7. Article
  8. Comparison ofJournal of biosciences · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Boris ShaskolskiyLaboratory for Molecular Diagnostics Technologies, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences Moscow, Russia.
Ekaterina DementievaLaboratory for Molecular Diagnostics Technologies, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences Moscow, Russia.
Arvo LeinsooLaboratory for Molecular Diagnostics Technologies, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences Moscow, Russia.
Anastassia RuninaState Research Center of Dermatovenerology and Cosmetology of the Russian Ministry of Health Moscow, Russia.
Denis VorobyevState Research Center of Dermatovenerology and Cosmetology of the Russian Ministry of Health Moscow, Russia.
Xenia PlakhovaState Research Center of Dermatovenerology and Cosmetology of the Russian Ministry of Health Moscow, Russia.
Alexey KubanovState Research Center of Dermatovenerology and Cosmetology of the Russian Ministry of Health Moscow, Russia.
Dmitrii DeryabinState Research Center of Dermatovenerology and Cosmetology of the Russian Ministry of Health Moscow, Russia.
Dmitry GryadunovLaboratory for Molecular Diagnostics Technologies, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences Moscow, Russia.
Engelhardt Institute of Molecular Biology · RUState Research Center for Dermatovenereology and Cosmetology · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we review sexually transmitted diseases (STDs) caused by pathogenic bacteria and vaginal infections which result from an overgrowth of opportunistic bacterial microflora. First, we describe the STDs, the corresponding pathogens and the antimicrobials used for their treatment. In addition to the well-known diseases caused by single pathogens (i.e., syphilis, gonococcal infections, and chlamydiosis), we consider polymicrobial reproductive tract infections (especially those that are difficult to effectively clinically manage). Then, we summarize the biochemical mechanisms that lead to antimicrobial resistance and the most recent data on the emergence of drug resistance in STD pathogens and bacteria associated with vaginosis. A large amount of research performed in the last 10-15 years has shed light on the enormous diversity of mechanisms of resistance developed by bacteria. A detailed understanding of the mechanisms of antimicrobials action and the emergence of resistance is necessary to modify existing drugs and to develop new ones directed against new targets.

Indexed as

antimicrobial resistanceantimicrobialsbacterial vaginosishuman reproductive systemsexually transmitted diseases

Identifiers

PMID27242760
PMCPMC4870398
OpenAlexW2408482466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.