ArticleFrontiers in microbiology2016
A Terpene Synthase Is Involved in the Synthesis of the Volatile Organic Compound Sodorifen of Serratia plymuthica 4Rx13.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Discovery and Biosynthesis of Farnesyl Pyrophosphate-Derived Noncanonical CJournal of the American Chemical Society · 2026Article
- Integrative Multi-Omics Identify Key Secondary Metabolites Linked to Acid Tolerance inMicroorganisms · 2025Article
- Evolution-guided engineering ofScience (New York, N.Y.) · 2024Article
- Fragmentation and [4 + 3] cycloaddition in sodorifen biosynthesis.Nature chemistry · 2023Article
- The possibility of using Serratia isolates for the production of biopreparations in the protection of plants against diseases and pests.Archives of microbiology · 2023Review
- Article
- Soil-derived bacteria endow Camellia weevil with more ability to resist plant chemical defense.Microbiome · 2022Article
- Two Apriona Species Sharing a Host Niche Have Different Gut Microbiome Diversity.Microbial ecology · 2022Article
- Bacterial terpenome.Natural product reports · 2021Review
- Reaction mechanism of the farnesyl pyrophosphate C-methyltransferase towards the biosynthesis of pre-sodorifen pyrophosphate by Serratia plymuthica 4Rx13.Scientific reports · 2021Article
- Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.Natural product reports · 2020Review
- The hidden enzymology of bacterial natural product biosynthesis.Nature reviews. Chemistry · 2019Article
- Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C.Scientific reports · 2017Article
- Carbon Catabolite Repression Regulates the Production of the Unique Volatile Sodorifen ofFrontiers in microbiology · 2017Article
- Analysis of the genomic sequences and metabolites of Serratia surfactantfaciens sp. nov. YD25BMC genomics · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria release a plethora of volatile organic compounds, including compounds with extraordinary structures. Sodorifen (IUPAC name: 1,2,4,5,6,7,8-heptamethyl-3-methylenebicyclo[3.2.1]oct-6-ene) is a recently identified and unusual volatile hydrocarbon that is emitted by the rhizobacterium Serratia plymuthica 4R×13. Sodorifen comprises a bicyclic ring structure solely consisting of carbon and hydrogen atoms, where every carbon atom of the skeleton is substituted with either a methyl or a methylene group. This unusual feature of sodorifen made a prediction of its biosynthetic origin very difficult and so far its biosynthesis is unknown. To unravel the biosynthetic pathway we performed genome and transcriptome analyses to identify candidate genes. One knockout mutant (SOD_c20750) showed the desired negative sodorifen phenotype. Here it was shown for the first time that this gene is indispensable for the synthesis of sodorifen and strongly supports the hypothesis that sodorifen descends from the terpene metabolism. SOD_c20750 is the first bacterial terpene cyclase isolated from Serratia spp. and Enterobacteriales. Homology modeling revealed a 3D structure, which exhibits a functional role of amino acids for intermediate cation stabilization (W325) and putative proton acception (Y332). Moreover, the size and hydrophobicity of the active site strongly indicates that indeed the enzyme may catalyze the unusual compound sodorifen.
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