ArticleFrontiers in microbiology2016
Probiotic Bacillus cereus Strains, a Potential Risk for Public Health in China.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 83 citations in OpenAlex.
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- Rapid Detection and Identification of Vancomycin-Sensitive Bacteria Using an Electrochemical Apta-Sensor.ACS omega · 2024Article
- Genomic Insights into the Pathogenicity and Drug-Resistance of aInfection and drug resistance · 2024Article
- Review
- Pathological changes of highly pathogenicThe veterinary quarterly · 2023Article
- Biological Characterization and Whole-Genome Analysis ofMicroorganisms · 2023Article
- The Genetic and Phenotypic Diversity ofMarine drugs · 2023Article
- Review
- Autoclaved Diet with Inactivated Spores ofAnimals : an open access journal from MDPI · 2022Article
- Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis.Cell death discovery · 2022Article
- Comparative Analysis of Bacillus cereus Group Isolates' Resistance Using Disk Diffusion and Broth Microdilution and the Correlation between Antimicrobial Resistance Phenotypes and Genotypes.Applied and environmental microbiology · 2022Article
- Draft Genome Sequences of NineMicrobiology resource announcements · 2022Article
- Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2022Review
- Commensal bacteria contribute to the growth of multidrug-resistantFrontiers in microbiology · 2022Article
- Conjugation acrossFrontiers in microbiology · 2022Review
- A virulentVirulence · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus cereus is an important cause of foodborne infectious disease and food poisoning. However, B. cereus has also been used as a probiotic in human medicine and livestock production, with low standards of safety assessment. In this study, we evaluated the safety of 15 commercial probiotic B. cereus preparations from China in terms of mislabeling, toxin production, and transferable antimicrobial resistance. Most preparations were incorrectly labeled, as they contained additional bacterial species; one product did not contain viable B. cereus at all. In total, 18 B. cereus group strains-specifically B. cereus and Bacillus thuringiensis-were isolated. Enterotoxin genes nhe, hbl, and cytK1, as well as the ces-gene were assessed by PCR. Enterotoxin production and cytotoxicity were confirmed by ELISA and cell culture assays, respectively. All isolated B. cereus group strains produced the enterotoxin Nhe; 15 strains additionally produced Hbl. Antimicrobial resistance was assessed by microdilution; resistance genes were detected by PCR and further characterized by sequencing, transformation and conjugation assays. Nearly half of the strains harbored the antimicrobial resistance gene tet(45). In one strain, tet(45) was situated on a mobile genetic element-encoding a site-specific recombination mechanism-and was transferable to Staphylococcus aureus and Bacillus subtilis by electro-transformation. In view of the wide and uncontrolled use of these products, stricter regulations for safety assessment, including determination of virulence factors and transferable antimicrobial resistance genes, are urgently needed.
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