ArticleFrontiers in microbiology2016
Horizontal Acquisition of a Multidrug-Resistance Module (R-type ASSuT) Is Responsible for the Monophasic Phenotype in a Widespread Clone of Salmonella Serovar 4,[5],12:i:.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 51 citations in OpenAlex.
- Comparative genomics of the monophasic variant ofMicrobiology spectrum · 2026Article
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- Genomic surveillance reveals escalating antimicrobial resistance and plasmid diversity in clinicalFrontiers in microbiology · 2026Article
- Localization of the origin of transfer for Salmonella genomic island 4 from Salmonella enterica serovar I 4,[5],12:i:.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- ISMicrobiology and molecular biology reviews : MMBR · 2024Review
- Antimicrobial consumption and resistance in bacteria from humans and food-producing animals: Fourth joint inter-agency report on integrated analysis of antimicrobial agent consumption and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals in the EU/EEA JIACRA IV - 2019-2021.EFSA journal. European Food Safety Authority · 2024Article
- Emergence and genomic characteristics of multi-drug-resistantMicrobial genomics · 2024Article
- Spread ofAntibiotics (Basel, Switzerland) · 2023Article
- Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.Emerging infectious diseases · 2023Article
- Increased phage resistance through lysogenic conversion accompanying emergence of monophasicMicrobial genomics · 2022Article
- Relationship and distribution of Salmonella enterica serovar I 4,[5],12:i:- strain sequences in the NCBI Pathogen Detection database.BMC genomics · 2022Article
- Nosocomial Pneumonia Caused in an Immunocompetent Patient by the Emergent Monophasic ST34 Variant ofAntibiotics (Basel, Switzerland) · 2022Article
- Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia.Nature communications · 2021Article
- Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.Scientific reports · 2021Article
- The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2018/2019.EFSA journal. European Food Safety Authority · 2021Article
- Colistin Resistance in Monophasic Isolates ofFrontiers in microbiology · 2021Article
- Identification of a Recently Dominant Sublineage inFrontiers in microbiology · 2021Article
- Sequence Analyses and Phenotypic Characterization Revealed Multidrug Resistant Gene Insertions in the Genomic Region Encompassing Phase 2 Flagellin EncodingFrontiers in microbiology · 2021Article
- Genotyping Study ofMicroorganisms · 2020Article
- Whole-genome epidemiology links phage-mediated acquisition of a virulence gene to the clonal expansion of a pandemicMicrobial genomics · 2020Article
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Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica serovar 4,[5],12:i:- is a monophasic variant of S. Typhimurium incapable of expressing the second-phase flagellar antigen (fljAB operon), and it is recognized to be one of the most prevalent serovars causing human infections. A clonal lineage characterized by phage type DT193, PulseNet PFGE profile STYMXB.0131 and multidrug resistance to ampicillin, streptomycin, sulphonamides and tetracycline (R-type ASSuT) is commonly circulating in Europe. In this study we determined the deletions affecting the fljAB operon and the resistance region responsible for the R-type ASSuT in a strain of Salmonella enterica serovar 4,5,12:i:- DT193/STYMXB.0131, through an approach based on PCRs and Southern blot hybridization of genomic DNA. Using a set of nine specific PCRs, the prevalence of the resistance region was assessed in a collection of 144 S. enterica serovar 4,[5],12:i:-/ASSuT/STYMXB.0131 strains isolated from Germany, Switzerland and Italy. A 28 kb-region is embedded between the loci STM2759 and iroB, replacing the DNA located in between, including the fljAB operon. It encompasses the genes bla TEM-1, strA-strB, sul2 and tet(B) responsible for the R-type ASSuT together with genes involved in plasmid replication and orfs of unknown function characteristically located on IncH1 plasmids. Its location and internal structure is fairly conserved in S. enterica serovar 4,[5],12:i:-/ASSuT/STYMXB.0131 strains regardless of the isolation source or country. Hence, in the S. enterica serovar 4,[5],12:i:-/ASSuT/STYMXB.0131 clonal lineage widespread in Germany, Switzerland and Italy, a resistance region derived from IncH1 plasmids has replaced the chromosomal region encoding the second flagellar phase and is an example of the stabilization of new plasmid-derived genetic material due to integration into the bacterial chromosome.
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