ArticleFrontiers in aging neuroscience2016
Attentional Control of Gait and Falls: Is Cholinergic Dysfunction a Common Substrate in the Elderly and Parkinson's Disease?
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Are attentional instruction and feedback type affect on learning of postural and supra-postural tasks?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Trial
- IMU-Based Analysis of Task-Dependent Associations Between Anticipatory Postural Adjustments and Gait Speed Under Dual-Task Conditions.Sensors (Basel, Switzerland) · 2026Article
- Transcranial Magnetic Stimulation in Parkinson's Disease and Parkinsonian Syndromes: A Narrative Expert Review.Life (Basel, Switzerland) · 2026Review
- Versatility of Transcranial Magnetic Stimulation: A Review of Diagnostic and Therapeutic Applications.Brain sciences · 2026Review
- Exploring gait automaticity and prefrontal brain activity during single and dual-task walking in aging and Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Vibration stimulation to the lower limbs improves freezing of gait and modifies cortical electrical activities in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Recent advances of transcranial electrical stimulation in healthy aging and Parkinson's disease: Effects on dual tasking.Journal of Parkinson's disease · 2025Review
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- Brain Networks Modulation during Simple and Complex Gait: A "Mobile Brain/Body Imaging" Study.Sensors (Basel, Switzerland) · 2024Article
- Attenuated afferent inhibition correlated with impaired gait performance in Parkinson's disease patients with freezing of gait.Frontiers in aging neuroscience · 2024Article
- Aberrant decision-making as a risk factor for falls in aging.Frontiers in aging neuroscience · 2024Review
- Cognitive-motor dual-task interference in Alzheimer's disease, Parkinson's disease, and prodromal neurodegeneration: A scoping review.Gait & posture · 2023Article
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait.Annals of clinical and translational neurology · 2023Article
- Exploring the effects of dopamine on sensorimotor inhibition and mobility in older adults.Experimental brain research · 2023Article
- Experimental environment improves the reliability of short-latency afferent inhibition.PloS one · 2023Article
- Olfaction and Physical Functioning in Older Adults: A Longitudinal Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- A Novel Way of Measuring Dual-Task Interference: The Reliability and Construct Validity of the Dual-Task Effect Battery in Neurodegenerative Disease.Neurorehabilitation and neural repair · 2022Article
- Anodal Transcranial Direct Current Stimulation Could Modulate Cortical Excitability and the Central Cholinergic System in Akinetic Rigid-Type Parkinson's Disease: Pilot Study.Frontiers in neurology · 2022Article
- Relationships Between Sensorimotor Inhibition and Mobility in Older Adults With and Without Parkinson's Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to address whether deficits in the central cholinergic activity may contribute to the increased difficulty to allocate attention during gait in the elderly with heightened risk of falls. We recruited 50 participants with a history of two or more falls (33 patients with Parkinson's Disease and 17 older adults) and 14 non-fallers age-matched adults. Cholinergic activity was estimated by means of short latency afferent inhibition (SAI), a transcranial magnetic stimulation (TMS) technique that assesses an inhibitory circuit in the sensorimotor cortex and is regarded as a global marker of cholinergic function in the brain. Increased difficulty to allocate attention during gait was evaluated by measuring gait performance under single and dual-task conditions. Global cognition was also assessed. Results showed that SAI was reduced in patients with PD than in the older adults (fallers and non-fallers) and in older adults fallers with respect to non-fallers. Reduction in SAI indicates less inhibition i.e., less cholinergic activity. Gait speed was reduced in the dual task gait compared to normal gait only in our faller population and changes in gait speed under dual task significantly correlated with the mean value of SAI. This association remained significant after adjusting for cognitive status. These findings suggest that central cholinergic activity may be a predictor of change in gait characteristics under dual tasking in older adults and PD fallers independently of cognitive status.
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