Evidence map›Paper›PMID 27242492›Full record

ArticleFrontiers in human neuroscience2016

Modulation of the Default Mode Network in First-Episode, Drug-Naïve Major Depressive Disorder via Acupuncture at Baihui (GV20) Acupoint.

Demao Deng, Hai Liao, Gaoxiong Duan, Yanfei Liu, Qianchao He, Huimei Liu, Lijun Tang, Yong Pang, Jien Tao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Demao DengDepartment of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Hai LiaoDepartment of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Gaoxiong DuanDepartment of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Yanfei LiuLife Science Research Center, School of Life Science and Technology, Xidian University Xi'an, China.
Qianchao HeDepartment of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Huimei LiuDepartment of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Lijun TangDepartment of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Yong PangDepartment of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Jien TaoDepartment of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China.
Guangxi University of Chinese Medicine · CNGuangxi University · CNXidian University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD. MATERIALS AND

methodsTwenty nine patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study. All the healthy subjects underwent 6-min resting-state functional magnetic resonance imaging (R-fMRI) scan. While patients underwent acupuncture stimulation for 20-min electro-acupuncture stimulation (EAS) at Baihui acupoint (GV20) and two 6-min R-fMRI scans before and after EAS. Based on the precuneus/posterior cingulate cortex (PC/PCC) as the seed region, functional connectivity (FC) method was adopted to examine abnormal DMN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the DMN in patients with MDD.

resultsCompared to healthy subjects, MDD patients had abnormal DMN. Moreover, results showed that EAS at GV20 induced increased FC between the PC/PCC and bilateral anterior cingulate cortex (ACC), and decreased FC between the PC/PCC and left middle prefrontal cortex, left angualr gyrus and bilateral hippocampus/parahippocampus (HIPP/paraHIPP) in patients with MDD, which were the main brain regions showing significant differences between the patients and healthy subjects.

conclusionOur findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the DMN in patients with first-episode, drug-naïve MDD. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical.

Indexed as

acupunctureBaihuifMRIfunctional connectivitymajor depressive disorder

Identifiers

PMID27242492
PMCPMC4869560
OpenAlexW2406091010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.