Evidence map›Paper›PMID 27242459›Full record

ArticleFrontiers in behavioral neuroscience2016

Retrieval and Reconsolidation Accounts of Fear Extinction.

Ravikumar Ponnusamy, Irina Zhuravka, Andrew M Poulos, Justin Shobe, Michael Merjanian, Jeannie Huang, David Wolvek, Pia-Kelsey O'Neill, Michael S Fanselow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Engrams of Fear Memory Attenuation.Advances in neurobiology · 2024
    Review
  3. Review
  4. Article
  5. Apparent reconsolidation interference without generalized amnesia.Progress in neuro-psychopharmacology & biological psychiatry · 2021
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ravikumar PonnusamyDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
Irina ZhuravkaDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
Andrew M PoulosDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
Justin ShobeDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
Michael MerjanianDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
Jeannie HuangDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
David WolvekDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
Pia-Kelsey O'NeillDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.
Michael S FanselowDepartments of Psychology, Psychiatry and Biobehavioral Sciences, and The Brain Research Institute, University of California Los Angeles, CA, USA.

Funding

Contextual Fear Differentiation, Sex Differences and AcetylcholineR01MH062122 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S · 2001 to 2021
$7.3M
NIMH NIH HHS R01 MH062122
6 · The paper itself

Abstract

Extinction is the primary mode for the treatment of anxiety disorders. However, extinction memories are prone to relapse. For example, fear is likely to return when a prolonged time period intervenes between extinction and a subsequent encounter with the fear-provoking stimulus (spontaneous recovery). Therefore there is considerable interest in the development of procedures that strengthen extinction and to prevent such recovery of fear. We contrasted two procedures in rats that have been reported to cause such deepened extinction. One where extinction begins before the initial consolidation of fear memory begins (immediate extinction) and another where extinction begins after a brief exposure to the consolidated fear stimulus. The latter is thought to open a period of memory vulnerability similar to that which occurs during initial consolidation (reconsolidation update). We also included a standard extinction treatment and a control procedure that reversed the brief exposure and extinction phases. Spontaneous recovery was only found with the standard extinction treatment. In a separate experiment we tested fear shortly after extinction (i.e., within 6 h). All extinction procedures, except reconsolidation update reduced fear at this short-term test. The findings suggest that strengthened extinction can result from alteration in both retrieval and consolidation processes.

Indexed as

anxiety disordersconsolidationextinctionfearmemoryreconsolidation

Identifiers

PMID27242459
PMCPMC4860411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.