ArticleFrontiers in neuroanatomy2016
New Insights in Trigeminal Anatomy: A Double Orofacial Tract for Nociceptive Input.
Article in Frontiers in neuroanatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Vagus nerve stimulation for primary headache disorders: An anatomical review to explain a clinical phenomenon.Cephalalgia : an international journal of headache · 2019Pooled it
- Brain-Wide Mapping and Synaptic Localization of C1QL3 Using a Novel Epitope-Tagged Knock-In Mouse.The Journal of comparative neurology · 2026Article
- Article
- ER stress-induced ITPR1/ANO1 signaling drives trigeminal neuropathic pain through calcium-dependent neuronal hyperexcitability.The journal of headache and pain · 2025Article
- Thalamic changes in patients with chronic facial pain.Neuroradiology · 2025Article
- Delineation of the trigeminal-lateral parabrachial-central amygdala tract in humans.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Exercise Influences the Brain's Metabolic Response to Chronic Cocaine Exposure in Male Rats.Journal of personalized medicine · 2024Article
- Somatotopic organization of the ventral nuclear group of the dorsal thalamus: deep brain stimulation for neuropathic pain reveals new insights into the facial homunculus.Brain structure & function · 2024Article
- Article
- Pain as a Guide in Glasgow Coma Scale Status for Neurological Assessment.The Malaysian journal of medical sciences : MJMS · 2023Article
- The trigeminal pathways.Journal of neurology · 2022Review
- Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- The thalamus in trigeminal neuralgia: structural and metabolic abnormalities, and influence on surgical response.BMC neurology · 2021Article
- Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice.Nature communications · 2021Article
- Increased risk of tinnitus following a trigeminal neuralgia diagnosis: a one-year follow-up study.The journal of headache and pain · 2020Article
- On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model.Frontiers in human neuroscience · 2020Article
- Article
- Trigeminal somatosensory evoked potential test as an evaluation tool for infraorbital nerve damage.Archives of craniofacial surgery · 2019Article
- Ex vivo visualization of the trigeminal pathways in the human brainstem using 11.7T diffusion MRI combined with microscopy polarized light imaging.Brain structure & function · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orofacial pain in patients relies on the anatomical pathways that conduct nociceptive information, originating from the periphery towards the trigeminal sensory nucleus complex (TSNC) and finally, to the thalami and the somatosensorical cortical regions. The anatomy and function of the so-called trigeminothalamic tracts have been investigated before. In these animal-based studies from the previous century, the intracerebral pathways were mapped using different retro- and anterograde tracing methods. We review the literature on the trigeminothalamic tracts focusing on these animal tracer studies. Subsequently, we related the observations of these studies to clinical findings using fMRI trials. The intracerebral trigeminal pathways can be subdivided into three pathways: a ventral (contralateral) and dorsal (mainly ipsilateral) trigeminothalamic tract and the intranuclear pathway. Based on the reviewed evidence we hypothesize the co-existence of an ipsilateral nociceptive conduction tract to the cerebral cortex and we translate evidence from animal-based research to the human anatomy. Our hypothesis differs from the classical idea that orofacial pain arises only from nociceptive information via the contralateral, ventral trigeminothalamic pathway. Better understanding of the histology, anatomy and connectivity of the trigeminal fibers could contribute to the discovery of a more effective pain treatment in patients suffering from various orofacial pain syndromes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.