ArticleFrontiers in cellular neuroscience2016
Dynamics of Mitochondrial Transport in Axons.
Article in Frontiers in cellular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.Ageing research reviews · 2022Pooled it
- Article
- Stick-slip motion and universal statistics of cargo transport within living cells.bioRxiv : the preprint server for biology · 2025Article
- IntracellularFrontiers in cellular and infection microbiology · 2025Article
- Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production.Frontiers in molecular neuroscience · 2025Review
- KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons.bioRxiv : the preprint server for biology · 2024Article
- Mitochondrial plasticity and synaptic plasticity crosstalk; in health and Alzheimer's disease.CNS neuroscience & therapeutics · 2024Review
- Mitochondria in Alzheimer's Disease Pathogenesis.Life (Basel, Switzerland) · 2024Review
- Mitochondrial dysfunction and Alzheimer's disease: pathogenesis of mitochondrial transfer.Frontiers in aging neuroscience · 2024Review
- TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport.Nature communications · 2023Article
- mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth.BMC biology · 2022Article
- Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?Metabolites · 2021Review
- Optimizing mitochondrial maintenance in extended neuronal projections.PLoS computational biology · 2021Article
- Multi-curvature micropatterns unveil distinct calcium and mitochondrial dynamics in neuronal networks.Lab on a chip · 2021Article
- Mitochondrial dysfunction in schizophrenia: With a focus on postmortem studies.Mitochondrion · 2021Article
- Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.Neuron · 2019Article
- Chain length of saturated fatty acids regulates mitochondrial trafficking and function in sensory neurons.Journal of lipid research · 2019Article
- Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.International journal of molecular sciences · 2018Article
- MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The role of mitochondria in axon development and regeneration.Developmental neurobiology · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only a limited number of mitochondria moving in the anterograde direction from the cell body arrive at the axon ends of mouse hippocampal neurons. Furthermore, we have derived a mathematical formula using the Fokker-Planck equation to characterize features of mitochondrial transport, and the equation could determine altered mitochondrial transport in axons overexpressing parkin. Our analysis will provide new insights into the dynamics of mitochondrial transport in axons of normal and unhealthy neurons.
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