ArticleFrontiers in cellular neuroscience2016
Brain State-Dependent Closed-Loop Modulation of Paired Associative Stimulation Controlled by Sensorimotor Desynchronization.
Article in Frontiers in cellular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Closed-loop transcranial alternating current stimulation (tACS) reduces cue reactivity and improves inhibitory control in methamphetamine use disorder with frequency and timing specificity.Molecular psychiatry · 2026Article
- EEG-timed neuromuscular stimulation shapes ipsilateral TMS-evoked motor responses in humans.Clinical neurophysiology practice · 2026Article
- On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders.Frontiers in human neuroscience · 2023Review
- Neurostimulation for Stroke Rehabilitation.Frontiers in neuroscience · 2021Review
- Brain-Machine Neurofeedback: Robotics or Electrical Stimulation?Frontiers in bioengineering and biotechnology · 2020Article
- State-Dependent Gain Modulation of Spinal Motor Output.Frontiers in bioengineering and biotechnology · 2020Article
- Beta rhythm events predict corticospinal motor output.Scientific reports · 2019Article
- Motor learning enhanced by combined motor imagery and noninvasive brain stimulation is associated with reduced short-interval intracortical inhibition.Brain and behavior · 2019Article
- Distinct Beta-band Oscillatory Circuits Underlie Corticospinal Gain Modulation.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Recruitment of Additional Corticospinal Pathways in the Human Brain with State-Dependent Paired Associative Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Reaction Time Predicts Brain-Computer Interface Aptitude.IEEE journal of translational engineering in health and medicine · 2018Article
- Proprioceptive Feedback Facilitates Motor Imagery-Related Operant Learning of Sensorimotor β-Band Modulation.Frontiers in neuroscience · 2017Article
- Plasticity of premotor cortico-muscular coherence in severely impaired stroke patients with hand paralysis.NeuroImage. Clinical · 2017Article
- Constraints and Adaptation of Closed-Loop Neuroprosthetics for Functional Restoration.Frontiers in neuroscience · 2017Article
- EEG-Neurofeedback as a Tool to Modulate Cognition and Behavior: A Review Tutorial.Frontiers in human neuroscience · 2017Article
- Hybrid Neuroprosthesis for the Upper Limb: Combining Brain-Controlled Neuromuscular Stimulation with a Multi-Joint Arm Exoskeleton.Frontiers in neuroscience · 2016Article
- Closed-Loop Task Difficulty Adaptation during Virtual Reality Reach-to-Grasp Training Assisted with an Exoskeleton for Stroke Rehabilitation.Frontiers in neuroscience · 2016Article
- What Turns Assistive into Restorative Brain-Machine Interfaces?Frontiers in neuroscience · 2016Article
- Closed-Loop Neuroprosthesis for Reach-to-Grasp Assistance: Combining Adaptive Multi-channel Neuromuscular Stimulation with a Multi-joint Arm Exoskeleton.Frontiers in neuroscience · 2016Article
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2 authors.
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Abstract
backgroundPairing peripheral electrical stimulation (ES) and transcranial magnetic stimulation (TMS) increases corticospinal excitability when applied with a specific temporal pattern. When the two stimulation techniques are applied separately, motor imagery (MI)-related oscillatory modulation amplifies both ES-related cortical effects-sensorimotor event-related desynchronization (ERD), and TMS-induced peripheral responses-motor-evoked potentials (MEP). However, the influence of brain self-regulation on the associative pairing of these stimulation techniques is still unclear.
objectiveThe aim of this pilot study was to investigate the effects of MI-related ERD during associative ES and TMS on subsequent corticospinal excitability.
methodThe paired application of functional electrical stimulation (FES) of the extensor digitorum communis (EDC) muscle and subsequent single-pulse TMS (110% resting motor threshold (RMT)) of the contralateral primary motor cortex (M1) was controlled by beta-band (16-22 Hz) ERD during MI of finger extension and applied within a brain-machine interface environment in six healthy subjects. Neural correlates were probed by acquiring the stimulus-response curve (SRC) of both MEP peak-to-peak amplitude and area under the curve (AUC) before and after the intervention.
resultThe application of approximately 150 pairs of associative FES and TMS resulted in a significant increase of MEP amplitudes and AUC, indicating that the induced increase of corticospinal excitability was mediated by the recruitment of additional neuronal pools. MEP increases were brain state-dependent and correlated with beta-band ERD, but not with the background EDC muscle activity; this finding was independent of the FES intensity applied.
conclusionThese results could be relevant for developing closed-loop therapeutic approaches such as the application of brain state-dependent, paired associative stimulation (PAS) in the context of neurorehabilitation.
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