ArticleFrontiers in neuroscience2016
Major Superficial White Matter Abnormalities in Huntington's Disease.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial.JAMA network open · 2023Trial
- Morphological similarity and white matter structural mapping of new daily persistent headache: a structural connectivity and tract-specific study.The journal of headache and pain · 2024Article
- Comparative analysis of the chimpanzee and human brain superficial structural connectivities.Brain structure & function · 2024Article
- Mapping the glial transcriptome in Huntington's disease using snRNAseq: selective disruption of glial signatures across brain regions.Acta neuropathologica communications · 2024Article
- Assessment of the Depiction of Superficial White Matter Using Ultra-High-Resolution Diffusion MRI.Human brain mapping · 2024Article
- Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia.Acta neuropathologica communications · 2024Article
- The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington's disease.Frontiers in aging neuroscience · 2024Review
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- In vivo mapping of the deep and superficial white matter connectivity in the chimpanzee brain.NeuroImage · 2023Article
- Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.Nature medicine · 2023Article
- Structural impairment in superficial and deep white matter in schizophrenia.Acta neuropsychiatrica · 2023Article
- Treatment with the Glycosphingolipid Modulator THI Rescues Myelin Integrity in the Striatum of R6/2 HD Mice.International journal of molecular sciences · 2023Article
- Depicting the anatomy of the gyral white matter:Brain communications · 2023Review
- Brain Alterations in Aged OVT73 Sheep Model of Huntington's Disease: An MRI Based Approach.Journal of Huntington's disease · 2022Article
- Machine learning to investigate superficial white matter integrity in early multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Oligodendroglial Heterogeneity in Neuropsychiatric Disease.Life (Basel, Switzerland) · 2021Review
- Broad white matter impairment in multiple system atrophy.Human brain mapping · 2021Article
- Mapping Short Association Fibers in the Early Cortical Visual Processing Stream Using In Vivo Diffusion Tractography.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Identification of Superficial White Matter Abnormalities in Alzheimer's Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging.Journal of Alzheimer's disease reports · 2020Article
- Increased and Decreased Superficial White Matter Structural Connectivity in Schizophrenia and Bipolar Disorder.Schizophrenia bulletin · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative disease effects. Therefore, it may be sensitive to Huntington's disease processes.
methodsStructural MRI data from 25 Pre-symptomatic subjects, 24 Huntington's disease patients and 49 healthy controls was run through a cortical pattern-matching program. The surface corresponding to the white matter directly below the cortical gray matter was then extracted. Individual subject's Diffusion Tensor Imaging (DTI) data was aligned to their structural MRI data. Diffusivity values along the white matter surface were then sampled at each vertex point. DTI measures with high spatial resolution across the superficial white matter surface were then analyzed with the General Linear Model to test for the effects of disease.
resultsThere was an overall increase in the axial and radial diffusivity across much of the superficial white matter (p < 0.001) in Pre-symptomatic subjects compared to controls. In Huntington's disease patients increased diffusivity covered essentially the whole brain (p < 0.001). Changes are correlated with genotype (CAG repeat number) and disease burden (p < 0.001).
conclusionsThis study showed broad abnormalities in superficial white matter even before symptoms are present in Huntington's disease. Since, the superficial white matter has a unique microstructure and function these abnormalities suggest it plays an important role in the disease.
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