Evidence map›Paper›PMID 27242272›Full record

Trial reportJournal of sleep research2016

Impact of continuous positive airway pressure (CPAP) on quality of life in patients with obstructive sleep apnea (OSA).

Salma Batool-Anwar, James L Goodwin, Clete A Kushida, James A Walsh, Richard D Simon, Deborah A Nichols, Stuart F Quan

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of sleep research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 83 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 9 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00051363 phase3completednot on this map

APPLES: Apnea Positive Pressure Long-Term Efficacy Study

TypeinterventionalSponsorStanford UniversityRan2002 to 2008Enrolled1,105ConditionsLung Diseases, Sleep Apnea Syndromes, SleepArmsActive CPAP, Sham CPAP
NCT06292325 completednot on this mapstarted 2023, after this paper: background citation

Psychological Aspects in Modifying Apnea/Hypopnea Indices and Nadir of Saturation in Obstructive Sleep Apnea Syndrome (OSA)

TypeobservationalSponsorFondazione Don Carlo Gnocchi ETSRan2023 to 2024Enrolled246ConditionsOsa SyndromeArmsContinuous Positive Airway Pressure (CPAP)
NCT06664450 recruitingnot on this mapstarted 2025, after this paper: background citation

Exploring Brain Fog Symptoms in Patients With Obstructive Sleep Apnea and CPAP Therapy Impact: A Pilot Study

Typeobservational_patient_registrySponsorFondazione Don Carlo Gnocchi ETSRan2025 to 2026Enrolled80ConditionsObstructive Sleep Apnea
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 9 syntheses or guidelines pooled it, 143 citations in OpenAlex.

  1. Pooled it
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  6. Long-term effects on clinical event, mental health, and related outcomes of CPAP for obstructive sleep apnea: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Pooled it
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  10. Trial
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  12. CPAP increases physical activity in obstructive sleep apnea with cardiovascular disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Trial
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  16. Article
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  19. Challenging barriers in OSA: Outcomes of "Down under" pharyngoplasty and coblation tongue channelling.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Salma Batool-AnwarDivision of Sleep and Circadian Disorders Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
James L GoodwinArizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA.
Clete A KushidaStanford University, Stanford, CA, USA.
James A WalshSt Luke's Hospital, Chesterfield, MO, USA.
Richard D SimonSt Mary Medical Center, Walla Walla, WA, USA.
Deborah A NicholsStanford University, Stanford, CA, USA.
Stuart F QuanDivision of Sleep and Circadian Disorders Medicine, Brigham and Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Stanford University · USArizona Science Center · USCircadian (United States) · USProvidence St. Mary Medical Center · USSt. Luke's Hospital · USUniversity of Arizona · US

Funding

APPLES: Apnea Positive Pressure Long-Term Efficacy StudyU01HL068060 · NHLBI · STANFORD UNIVERSITY · PI KUSHIDA, CLETE A · 2002 to 2007
$14.1M
NHLBI NIH HHS U01 HL068060
6 · The paper itself

Abstract

Obstructive sleep apnea is a chronic illness with increasing prevalence. In addition to associated cardiovascular comorbidities, obstructive sleep apnea syndrome has been linked to poor quality of life, occupational accidents, and motor vehicle crashes secondary to excessive daytime sleepiness. Although continuous positive airway pressure is the gold standard for sleep apnea treatment, its effects on quality of life are not well defined. In the current study we investigated the effects of treatment on quality of life using the data from the Apnea Positive Pressure Long-term Efficacy Study (APPLES), a randomized controlled trial of continuous positive airway pressure (CPAP) versus sham CPAP. The Calgary Sleep Apnea Quality of Life Index (SAQLI) was used to assess quality of life. Overall we found no significant improvement in quality of life among sleep apnea patients after CPAP treatment. However, after stratifying by OSA severity, it was found that long-term improvement in quality of life might occur with the use of CPAP in people with severe and possibly moderate sleep apnea, and no demonstrable improvement in quality of life was noted among participants with mild obstructive sleep apnea.

Indexed as

Continuous Positive Airway PressureQuality of LifeSleep Apnea, ObstructiveAffectDepressionFemaleHumansMaleMiddle AgedOdds RatioSleep Stagesadherencecontinuous positive airway pressuredaytime sleepinesssleep apnea quality of life

Identifiers

PMID27242272
PMCPMC5436801
OpenAlexW2410202669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.