ArticleFree radical biology & medicine2016
The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.
Article in Free radical biology & medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 101 citations in OpenAlex.
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- Disease mechanisms revealed in the P23H opsin knock-in mouse model of retinitis pigmentosa.PNAS nexus · 2026Article
- Review
- Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality.Redox biology · 2024Article
- Sulfinamide Formation from the Reaction of Bacillithiol and Nitroxyl.ACS chemical biology · 2023Article
- Persulfide Biosynthesis Conserved Evolutionarily in All Organisms.Antioxidants & redox signaling · 2023Review
- Actions of Thiols, Persulfides, and Polysulfides as Free Radical Scavenging Antioxidants.Antioxidants & redox signaling · 2023Review
- Supersulphides provide airway protection in viral and chronic lung diseases.Nature communications · 2023Article
- Reactive Sulfur Species Omics Analysis in the Brain Tissue of the 5xFAD Mouse Model of Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2023Article
- Diverse Possibilities of Si-Based Agent, a Unique New Antioxidant.Antioxidants (Basel, Switzerland) · 2023Review
- Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism.Antioxidants (Basel, Switzerland) · 2023Article
- Interactions of reactive sulfur species with metalloproteins.Redox biology · 2023Review
- 3-Mercaptopyruvate sulfur transferase is a protein persulfidase.Nature chemical biology · 2023Article
- The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling.Antioxidants & redox signaling · 2023Review
- Inhibition of fungal pathogenicity by targeting the HScience advances · 2022Article
- The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species.Redox biology · 2022Article
- Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers.Angewandte Chemie (International ed. in English) · 2022Article
- A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent.Scientific reports · 2022Article
- Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems.Antioxidants & redox signaling · 2022Review
- Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.Antioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
The recent discovery of significant hydropersulfide (RSSH) levels in mammalian tissues, fluids and cells has led to numerous questions regarding their possible physiological function. Cysteine hydropersulfides have been found in free cysteine, small molecule peptides as well as in proteins. Based on their chemical properties and likely cellular conditions associated with their biosynthesis, it has been proposed that they can serve a protective function. That is, hydropersulfide formation on critical thiols may protect them from irreversible oxidative or electrophilic inactivation. As a prelude to understanding the possible roles and functions of hydropersulfides in biological systems, this study utilizes primarily chemical experiments to delineate the possible mechanistic chemistry associated with cellular protection. Thus, the ability of hydropersulfides to protect against irreversible electrophilic and oxidative modification was examined. The results herein indicate that hydropersulfides are very reactive towards oxidants and electrophiles and are modified readily. However, reduction of these oxidized/modified species is facile generating the corresponding thiol, consistent with the idea that hydropersulfides can serve a protective function for thiol proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.