ArticleChemical communications (Cambridge, England)2016
Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE.
Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Parahydrogen-Induced Hyperpolarization of Gases.Angewandte Chemie (International ed. in English) · 2020Review
- Metabolic and Molecular Imaging with Hyperpolarised Tracers.Molecular imaging and biology · 2018Review
- Direct and indirect hyperpolarisation of amines usingChemical science · 2018Article
- Long-LivedThe journal of physical chemistry letters · 2017Article
- SABRE hyperpolarisation of vitamin B3 as a function of pH.Chemical science · 2017Article
- NMR SLIC Sensing of Hydrogenation Reactions Using Parahydrogen in Low Magnetic Fields.The journal of physical chemistry. C, Nanomaterials and interfaces · 2016Article
- Using signal amplification by reversible exchange (SABRE) to hyperpolariseChemical communications (Cambridge, England) · 2016Article
- A HyperpolarizableAngewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the signal amplification by reversible exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90% efficiency into the new state, which in this case has a 27 second lifetime.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.