ArticleeLife2016
Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 155 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 1 synthesis or guideline pooled it, 364 citations in OpenAlex.
- Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane.International journal of molecular sciences · 2022Pooled it
- Methylated memories mechanism, evidence, and skepticism in plant transgenerational epigenetic inheritance.Protoplasma · 2026Review
- Hydrostatic pressure-induced heritable variation in rice is associated with transposon mobilization, DNA methylation changes, and transcriptional reprogramming.Plant cell reports · 2026Article
- Learning in plants: A conceptual and experimental primer.Learning & behavior · 2026Article
- Molecular and transcriptional regulation of plant defense responses to aphid infestation.Stress biology · 2026Review
- Advances in the study of the role of epigenetic mechanisms in plant growth and response to stress.Horticulture research · 2026Article
- Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies.The New phytologist · 2026Review
- Heterochromatin reorganization associated with the transcriptional reprogramming under viral infection in Arabidopsis.Nucleic acids research · 2026Article
- Inheritable Epigenetic Memory Induced by Parental Salt Stress Influences Transgenerational Plasticity ofEcology and evolution · 2026Article
- Photorespiration is linked to DNA methylation by formate as a one-carbon source.Nature plants · 2026Article
- DNA Methylation Dynamics in Plant Abiotic Stress Response: Mechanisms, Memory, and Breeding Applications.Genes · 2026Review
- Ecological Memory in Plants: Epigenetic Integration of Abiotic Stress and Climate Change.Plants (Basel, Switzerland) · 2026Review
- Flavonoids in Plant Salt Stress Responses: Biosynthesis, Regulation, Functions, and Signaling Networks.Plants (Basel, Switzerland) · 2026Review
- Epigenetic Regulation of Salt Stress Responses in Rice: Mechanisms and Prospects for Enhancing Tolerance.Epigenomes · 2025Review
- Regulation of DNA Methylation in Peanut Leaves and Roots: Uncovering the Molecular Mechanisms for Increased Yield After Single-Seed Sowing.Plant biotechnology journal · 2025Article
- Gaining insights into epigenetic memories through artificial intelligence and omics science in plants.Journal of integrative plant biology · 2025Review
- Maternal environmental effects and climate-smart seeds: unlocking epigenetic inheritance for crop innovation in the seed industry.The Plant journal : for cell and molecular biology · 2025Article
- Molecular Mechanisms of Plant Stress Memory: Roles of Non-Coding RNAs and Alternative Splicing.Plants (Basel, Switzerland) · 2025Review
- Heat Priming and Heat Stress Enhance Transgenerational Heat Tolerance in the Early Growth Stages ofPlants (Basel, Switzerland) · 2025Article
- The Good, the Bad, and the Epigenetic: Stress-Induced Metabolite Regulation and Transgenerational Effects.Epigenomes · 2025Review
95 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal 'short-term stress memory' with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.