Evidence map›Paper›PMID 27241967›Full record

ReviewEndocrinology and metabolism clinics of North America2016

Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.

Constantine A Stratakis

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Endocrinology and metabolism clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03831958 (Long-Term Follow-UP of Survivors of Pediatric Cushing Disease), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03831958 recruitingnot on this mapstarted 2019, after this paper: background citation

Long-Term Follow-UP of Survivors of Pediatric Cushing Disease

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2019 to 2040Enrolled600ConditionsCushing Disease
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Adrenal Cushing's syndrome in children.Frontiers in endocrinology · 2023
    Review
  3. Article
  4. Treatment of Primary Pigmented Nodular Adrenocortical Disease.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2022
    Review
  5. Article
  6. Article
  7. Observational
  8. Cushing's Disease.Journal of clinical medicine · 2019
    Review
  9. Large Genomic Aberrations in Corticotropinomas Are Associated With Greater Aggressiveness.The Journal of clinical endocrinology and metabolism · 2019
    Article
  10. Article
  11. Article
  12. SELLA TURCICA 3T MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF CUSHING'S DISEASE IN CHILDREN: TWO CASE REPORTS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2019
    Article
  13. Incidence of Autoimmune and Related Disorders After Resolution of Endogenous Cushing Syndrome in Children.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2018
    Article
  14. Review
  15. Article
  16. Review
  17. Somatic USP8 Gene Mutations Are a Common Cause of Pediatric Cushing Disease.The Journal of clinical endocrinology and metabolism · 2017
    Article
  18. Flushing in (neuro)endocrinology.Reviews in endocrine & metabolic disorders · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Constantine A StratakisSection on Endocrinology & Genetics (SEGEN), NICHD, NIH, Building 10, CRC, East Laboratories, Room 1-3330, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: stratakc@mail.nih.gov.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8M
Texas Tech Center for Translational Research and Rural Health - Research Capacity CoreU54MD020892 · NIMHD · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Lance R. McMahon, Naima Moustaid-Moussa · 2026 to 2026
$10.0M
Intramural NIH HHS ZIA HD008920NIMHD NIH HHS U54 MD020892
6 · The paper itself

Abstract

Endogenous Cushing syndrome (CS) in pediatrics is rare; it may be caused by tumors that produce corticotropin in the pituitary gland or elsewhere, tumors that produce corticotropin-releasing hormone anywhere, and adrenocortical masses that produce cortisol. Adrenocortical cancer is a rare cause of CS in children but should be excluded first. CS in children is often caused by germline or somatic mutations with implications for patient prognosis and for their families. CS should be recognized early in children; otherwise, it can lead to significant morbidity and mortality. Patients with suspected CS should be referred to specialized clinical centers for workup.

Indexed as

Adrenal Cortex NeoplasmsAdrenocorticotropic HormoneChildCorticotropin-Releasing HormoneCushing SyndromeHumansPediatricsAdrenocorticotropic HormoneCorticotropin-Releasing HormoneAdrenal glandAIP geneARMC5 geneCyclic AMP (cAMP)GNAS1 genePituitary glandPRKAR1A geneUSP8 gene

Identifiers

PMID27241967
PMCPMC4889872
OpenAlexW2396394490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.