ArticleJournal of mathematical biology2017
A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization.
Article in Journal of mathematical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of chromatin-lamina attachment on extra-long-range chromatin interactions.Biophysical journal · 2026Article
- Phase-field modeling of border cell cluster migration in Drosophila.PLoS computational biology · 2026Article
- The Role of Lamins in Genome Organisation: A Modelling Perspective.Sub-cellular biochemistry · 2025Review
- Consistencies and contradictions in different polymer models of chromatin architecture.Computational and structural biotechnology journal · 2023Review
- The extra-embryonic space and the local contour are crucial geometric constraints regulating cell arrangement.Development (Cambridge, England) · 2022Article
- Modeling and simulation of cell nuclear architecture reorganization process.Journal of computational physics · 2022Article
- Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells.Biophysics and physicobiology · 2022Article
- The Role of Cytoplasmic MEX-5/6 Polarity in Asymmetric Cell Division.Bulletin of mathematical biology · 2021Article
- Article
- Mesoscale Modeling of Nucleosome-Binding Antibody PL2-6: Mono- versus Bivalent Chromatin Complexes.Biophysical journal · 2020Article
- Mesoscale Liquid Model of Chromatin Recapitulates Nuclear Order of Eukaryotes.Biophysical journal · 2020Article
- Role of dynamic nuclear deformation on genomic architecture reorganization.PLoS computational biology · 2019Article
- Role of domain in pattern formation.Development, growth & differentiation · 2017Review
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4 authors at 1 institution in 1 country.
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Abstract
Specific features of nuclear architecture are important for the functional organization of the nucleus, and chromatin consists of two forms, heterochromatin and euchromatin. Conventional nuclear architecture is observed when heterochromatin is enriched at nuclear periphery, and it represents the primary structure in the majority of eukaryotic cells, including the rod cells of diurnal mammals. In contrast to this, inverted nuclear architecture is observed when the heterochromatin is distributed at the center of the nucleus, which occurs in the rod cells of nocturnal mammals. The inverted architecture found in the rod cells of the adult mouse is formed through the reorganization of conventional architecture during terminal differentiation. Although a previous experimental approach has demonstrated the relationship between these two nuclear architecture types at the molecular level, the mechanisms underlying long-range reorganization processes remain unknown. The details of nuclear structures and their spatial and temporal dynamics remain to be elucidated. Therefore, a comprehensive approach, using mathematical modeling, is required, in order to address these questions. Here, we propose a new mathematical approach to the understanding of nuclear architecture dynamics using the phase-field method. We successfully recreated the process of nuclear architecture reorganization, and showed that it is robustly induced by physical features, independent of a specific genotype. Our study demonstrates the potential of phase-field method application in the life science fields.
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