ArticleSocial psychiatry and psychiatric epidemiology2016
Increased risk of fracture in patients with bipolar disorder: a nationwide cohort study.
Article in Social psychiatry and psychiatric epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lithium use and risk of fracture: a systematic review and meta-analysis of observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Pooled it
- The silent struggle of ageing with SMI: a narrative review of physical health disparities in older adults with serious mental illness.Social psychiatry and psychiatric epidemiology · 2026Review
- Bipolar disorder medications are associated with increased odds of fracture nonunion.Archives of orthopaedic and trauma surgery · 2025Article
- Association Between Lithium Use and Periprosthetic Fracture After Total Hip Arthroplasty.Arthroplasty today · 2025Article
- Rates of fractures by medication type in patients with bipolar disorder: A retrospective cohort analysis.Journal of orthopaedics · 2025Article
- Causal associations of brain structure with bone mineral density: a large-scale genetic correlation study.Bone research · 2023Article
- Bipolar Disorder and Bone Mineral Density Z-Scores in Relation to Clinical Characteristics and Lithium Medication.Journal of clinical medicine · 2022Article
- Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder.Frontiers in psychiatry · 2020Article
- Association Between Bipolar Disorder and Low Bone Mass: A Cross-Sectional Study With Newly Diagnosed, Drug-Naïve Patients.Frontiers in psychiatry · 2020Article
- Risk and outcomes of fracture in peripheral arterial disease patients: two nationwide cohort studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBipolar disorder (BD) is a systemic inflammatory disease, and disrupted bone metabolism due to the inflammatory process can cause fracture. Despite evidence of an association between lower bone mineral density and an increased risk of fracture among patients with depression, schizophrenia, and anorexia nervosa, whether BD is a risk factor for subsequent fracture is unknown. To determine the association between BD and fracture and to examine the risk factors for fracture among patients with BD.
methodsIn this study, we enrolled patients diagnosed with BD from the Taiwan National Health Insurance Research Database. Patients newly diagnosed with BD (ICD-9-CM 296) from 2001 to 2008 were included in the BD cohort, and the date of the initial diagnosis of BD was used as the index date. The comparison cohort, comprising participants without BD, was frequency matched to the BD cohort by age, sex, and index year, and the occurrence of fracture was evaluated in both cohorts.
resultsThe BD and comparison cohorts were comprised of 47,271 patients with BD and 1,89,084 frequency-matched participants without BD, respectively. The incidence of fracture was higher among patients with BD than among the controls. Cox models showed that BD was an independent risk factor for fracture irrespective of comorbidities [hazard ratio (HR) = 1.79, 95 % confidence interval (CI) = 1.73-1.84, p < .001].
conclusionOur study showed that patients with BD have a higher risk of subsequent fracture. Additional prospective clinical studies investigating the relationship between BD and fracture are warranted.
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