ArticleScientific reports2016
A TonB-dependent receptor regulates antifungal HSAF biosynthesis in Lysobacter.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Hfq modulates system-wide regulatory networks controlling biocontrol property inSynthetic and systems biotechnology · 2026Article
- Immunopeptidome Landscape DuringInternational journal of molecular sciences · 2025Article
- A relationship between body size and the gut microbiome suggests a conservation strategy.Microbiology spectrum · 2025Article
- Shotgun metagenomic insights into secondary metabolite biosynthetic gene clusters reveal taxonomic and functional profiles of microbiomes in natural farmland soil.Scientific reports · 2024Article
- The First Homologous Expression System for the β-Lytic Protease ofInternational journal of molecular sciences · 2022Article
- Effect of Ferredoxin Receptor FusA on the Virulence Mechanism ofFrontiers in cellular and infection microbiology · 2022Article
- Deletion ofFrontiers in microbiology · 2021Article
- An iTRAQ-Based Comparative Proteomics Analysis of the Biofilm and Planktonic States ofInternational journal of molecular sciences · 2020Article
- Altered Gut Microbiota and Immunity DefinesFrontiers in immunology · 2020Article
- Efficient production of heat-stable antifungal factor through integrating statistical optimization with a two-stage temperature control strategy in Lysobacter enzymogenes OH11.BMC biotechnology · 2018Article
- Transcriptomics Analysis of the Chinese Pear Pathotype ofInternational journal of molecular sciences · 2018Article
- Indole-Induced Reversion of Intrinsic Multiantibiotic Resistance in Lysobacter enzymogenes.Applied and environmental microbiology · 2017Article
- Transcriptional and Antagonistic Responses of Biocontrol StrainFrontiers in microbiology · 2017Article
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Authors and funding
8 authors.
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Abstract
Lysobacter species are Gram-negative bacteria that are emerging as new sources of antibiotics, including HSAF (Heat Stable Antifungal Factor), which was identified from L. enzymogenes with a new mode of action. LesR, a LuxR solo, was recently shown to regulate the HSAF biosynthesis via an unidentified mechanism in L. enzymogenes OH11. Here, we used a comparative proteomic approach to identify the LesR targets and found that LesR influenced the expression of 33 proteins belonging to 10 functional groups, with 9 proteins belonging to the TBDR (TonB-Dependent Receptor) family. The fundamental role of bacterial TBDR in nutrient uptake motivates us to explore their potential regulation on HSAF biosynthesis which is also modulated by nutrient condition. Six out of 9 TBDR coding genes were individually in-frame deleted. Phenotypic and gene-expression assays showed that TBDR7, whose level was lower in a strain overexpressing lesR, was involved in regulating HSAF yield. TBDR7 was not involved in the growth, but played a vital role in transcribing the key HSAF biosynthetic gene. Taken together, the current lesR-based proteomic study provides the first report that TBDR7 plays a key role in regulating antibiotic (HSAF) biosynthesis, a function which has never been found for TBDRs in bacteria.
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