Evidence map›Paper›PMID 27241241›Full record

ReviewNature reviews. Nephrology2016

The role of neutrophils and NETosis in autoimmune and renal diseases.

Sarthak Gupta, Mariana J Kaplan

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07721857 (Dynamic Changes of Neutrophil Extracellular Traps in Lupus Nephritis and Their Role in Predicting Treatment Response.), which is not on this map. Cited by 253 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed, 8 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07721857 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Dynamic Changes of Neutrophil Extracellular Traps in Lupus Nephritis and Their Role in Predicting Treatment Response.

TypeobservationalSponsorAssiut UniversityRan2026 to 2028Enrolled100ConditionsLupus Nephritis (LN)ArmsSerum Neutrophil Extracellular Traps
3 · Its place in the literature

Who cites it

253 citing papers in PubMed, 8 syntheses or guidelines pooled it, 428 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Pooled it
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  7. Neutrophil Extracellular Traps (NETs) and Vasculitis.International journal of medical sciences · 2021
    Pooled it
  8. Pooled it
  9. Trial
  10. Article
  11. Review
  12. Review
  13. Review
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  18. Review
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193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sarthak GuptaNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Systemic Autoimmunity Branch, Intramural Research Program, National Institutes of Health, Room 6D 47C, 10 Center Drive, Bethesda, MD 20892-1930, USA.
Mariana J KaplanNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Systemic Autoimmunity Branch, Intramural Research Program, National Institutes of Health, Room 6D 47C, 10 Center Drive, Bethesda, MD 20892-1930, USA.
National Institute of Arthritis and Musculoskeletal and Skin Diseases · US

Funding

Clinical Support Services for the NIAMS Intramural Research ProgramZIDAR041180 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$119.2M
Systemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5M
Intramural NIH HHS Z99 AR999999
6 · The paper itself

Abstract

Systemic autoimmune diseases are a group of disorders characterized by a failure in self-tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these diseases occur as a multistep process in which environmental factors have key roles in the development of abnormal innate and adaptive immune responses. Experimental evidence collected in the past decade suggests that neutrophils - the most abundant type of white blood cell - might have an important role in the pathogenesis of these diseases by contributing to the initiation and perpetuation of immune dysregulation through the formation of neutrophil extracellular traps (NETs), synthesis of proinflammatory cytokines and direct tissue damage. Many of the molecules externalized through NET formation are considered to be key autoantigens and might be involved in the generation of autoimmune responses in predisposed individuals. In several systemic autoimmune diseases, the imbalance between NET formation and degradation might increase the half-life of these lattices, which could enhance the exposure of the immune system to modified autoantigens and increase the capacity for NET-induced organ damage. This Review details the role of neutrophils and NETs in the pathophysiology of systemic autoimmune diseases, including their effect on renal damage, and discusses neutrophil targets as potential novel therapies for these diseases.

Indexed as

AnimalsAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisAutoimmune DiseasesExtracellular TrapsHumansKidney DiseasesLupus Erythematosus, SystemicNeutrophils

Identifiers

PMID27241241
PMCPMC5510606
OpenAlexW2409717815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.