Evidence map›Paper›PMID 27241213›Full record

ArticleActa neurologica Scandinavica2017

Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson's disease.

N R Williams, B S Bentzley, G L Sahlem, J Pannu, J E Korte, G Revuelta, E B Short, M S George

Open access · greenAbstract read
In one paragraph

Article in Acta neurologica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

N R WilliamsDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
B S BentzleyDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
G L SahlemDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
J PannuDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1030-8776
J E KorteDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
G RevueltaDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
E B ShortDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
M S GeorgeDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · USStanford Medicine · US

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
TRAINING PROGRAM FOR MEDICAL SCIENTISTST32GM008716 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DEMORE, NANCY · 1999 to 2024
$9.3M
Drug Abuse Research Training (DART) ProgramR25DA020537 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KATHLEEN T. BRADY, Sudie E Back · 2006 to 2026
$6.3M
Identification of Gait and Imaging Markers for Freezing of Gait in Parkinson's DiseaseK23NS091391 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI REVUELTA, GONZALO JAVIER · 2015 to 2019
$982k
The Role of Orexin and Subthalamic Nucleus in Cocaine DemandF30DA035065 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BENTZLEY, BRANDON S · 2013 to 2015
$128k
NCATS NIH HHS UL1 TR000062NIDA NIH HHS F30 DA035065NIDA NIH HHS R25 DA020537NIGMS NIH HHS P20 GM109040NIGMS NIH HHS T32 GM008716NINDS NIH HHS K23 NS091391
6 · The paper itself

Abstract

objectivesElectroconvulsive therapy (ECT) has demonstrated efficacy in treating core symptoms of Parkinson's disease (PD); however, widespread use of ECT in PD has been limited due to concern over cognitive burden. We investigated the use of a newer ECT technology known to have fewer cognitive side effects (right unilateral [RUL] ultra-brief pulse [UBP]) for the treatment of medically refractory psychiatric dysfunction in PD. MATERIALS AND

methodsThis open-label pilot study included 6 patients who were assessed in the motoric, cognitive, and neuropsychiatric domains prior to and after RUL UBP ECT. Primary endpoints were changes in total score on the HAM-D-17 and GDS-30 rating scales.

resultsPatients were found to improve in motoric and psychiatric domains following RUL UBP ECT without cognitive side effects, both immediately following ECT and at 1-month follow-up.

conclusionsThis study demonstrates that RUL UBP ECT is safe, feasible, and potentially efficacious in treating multiple domains of PD, including motor and mood, without clear cognitive side effects.

Indexed as

AgedDepressionElectroconvulsive TherapyFemaleHumansMaleMiddle AgedParkinson DiseasePilot Projectsdepressionelectroconvulsive therapyParkinson's diseaseultra-brief pulse

Identifiers

PMID27241213
PMCPMC5133197
OpenAlexW2419109727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.