Evidence map›Paper›PMID 27241067›Full record

ArticleNeurourology and urodynamics2017

A pilot study to measure dynamic elasticity of the bladder during urodynamics.

Andrew F Colhoun, Adam P Klausner, Anna S Nagle, Ashley W Carroll, Robert W Barbee, Paul H Ratz, John E Speich

Open access · bronzeAbstract read
In one paragraph

Article in Neurourology and urodynamics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  8. NEW CONCEPTS IN BLADDER SENSATION AND URINARY URGENCY.Current bladder dysfunction reports · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew F ColhounDivision of Urology/Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Adam P KlausnerDivision of Urology/Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Anna S NagleDepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University School of Engineering, Richmond, Virginia.
Ashley W CarrollDepartment of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Robert W BarbeeDepartments of Emergency Medicine and Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Paul H RatzDepartments of Biochemistry and Molecular Biology and Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
John E SpeichDepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University School of Engineering, Richmond, Virginia.
Virginia Commonwealth University · US

Funding

The Detrusor Tension Sensor: A Model for Novel Cystometrics in Overactive BladderR01DK101719 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI KLAUSNER, ADAM PHILIP, SPEICH, JOHN E · 2015 to 2023
$2.4M
NIDDK NIH HHS R01 DK101719
6 · The paper itself

Abstract

aimsPrevious studies using isolated strips of human detrusor muscle identified adjustable preload tension, a novel mechanism that acutely regulates detrusor wall tension. The purpose of this investigation was to develop a method to identify a correlate measure of adjustable preload tension during urodynamics.

methodsPatients reporting urgency most or all of the time based on ICIq-OAB survey scores were prospectively enrolled in an extended repeat fill-and-empty urodynamics study designed to identify a correlate of adjustable preload tension which we now call "dynamic elasticity." Cystometric capacity was determined during initial fill. Repeat fills to defined percentages of capacity with passive emptying (via syringe aspiration) were performed to strain soften the bladder. A complete fill with active voiding was included to determine whether human bladder exhibits reversible strain softening.

resultsFive patients completed the extended urodynamics study. Intravesical pressure (p

conclusionsImproved understanding of dynamic elasticity in the human bladder could lead to both improved sub-typing and novel treatments of overactive bladder. Neurourol. Urodynam. 36:1086-1090, 2017. © 2016 Wiley Periodicals, Inc.

Indexed as

ElasticityUrodynamicsAdultBiomechanical PhenomenaFemaleHumansLower Urinary Tract SymptomsMiddle AgedMuscle, SmoothOrgan SizePilot ProjectsPressureStress, MechanicalUrinary BladderUrinary Bladder, Overactivebiomechanicscomplianceoveractive detrusor functionurinary bladderurodyanmics

Identifiers

PMID27241067
PMCPMC5133175
OpenAlexW2435389226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.