SynthesisCNS drugs2016
Identifying and Managing Pain in People with Alzheimer's Disease and Other Types of Dementia: A Systematic Review.
Synthesis in CNS drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 8 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- A Systematic Review Evaluating Pain Assessment Strategies for Patients With Dementia in the Emergency Department: The Geriatric ED Guidelines 2.0.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Pooled it
- A systematic review of prevalence of pain in nursing home residents with dementia.BMC geriatrics · 2023Pooled it
- Family Caregiver Challenges in Pain Management for Patients with Advanced Illnesses: A Systematic Review.Journal of palliative medicine · 2022Pooled it
- Does ethnicity affect pain management for people with advanced disease? A mixed methods cross-national systematic review of 'very high' Human Development Index English-speaking countries.BMC palliative care · 2022Pooled it
- Algorithm-based pain management for people with dementia in nursing homes.The Cochrane database of systematic reviews · 2022Pooled it
- A European Academy of Neurology guideline on medical management issues in dementia.European journal of neurology · 2020Guideline
- The Liverpool Care Pathway: discarded in cancer patients but good enough for dying nursing home patients? A systematic review.BMC medical ethics · 2017Pooled it
- Pain-Reducing Effects of Physical Therapist-Delivered Interventions: A Systematic Review of Randomized Trials Among Older Adults With Dementia.Journal of geriatric physical therapy (2001)Pooled it
- Effects of timely case conferencing between general practitioners and specialist palliative care services on symptom burden in patients with advanced chronic disease: results of the cluster-randomised controlled KOPAL trial.BMC palliative care · 2024Trial
- Chronic pain in Alzheimer disease and the role of neuroimmune interactions.Pharmacological reviews · 2026Review
- Pain in Alzheimer's Disease: Disrupted Multilevel Integration of Nociception, Affective Processing and Clinical Expression Across Clinical and Preclinical Evidence.Life (Basel, Switzerland) · 2026Review
- Patient-level evaluation of smartwatch-based pain and dehydration detection in nursing home residents: a prospective observational study.Frontiers in digital health · 2026Article
- Falls and Fractures Among Medicare Beneficiaries Concurrently Receiving Anti-Dementia Drugs and Potentially Risky Medications.Medical care · 2025Article
- Assessing and Managing Pain in Dementias: Insights From Interdisciplinary Text Message Communications.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025Article
- Evaluation of the psychometric properties of PainChek in older general hospital patients with dementia.Age and ageing · 2025Article
- Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease-A Review.Journal of biochemical and molecular toxicology · 2025Review
- Exercise-Based Pain Interventions for People with Dementia Using a Biopsychosocial-Environmental (BPSE) Model.Current geriatrics reports · 2025Review
- Validity and reliability of the Pain Assessment in Impaired Cognition 15 (PAIC15) observation scale in persons with aphasia.BMC neurology · 2024Article
- Pain Management in Cognitively Impaired Older Adults.International journal of nursing and health care research · 2024Article
- Modifying a multidisciplinary method to address challenging behavior in nursing home residents with dementia to involve family caregivers.Frontiers in dementia · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivePain in patients with Alzheimer's disease is a complex issue; these patients suffer from the common causes of acute and chronic pain, and some also have neuropathic or nociceptive pain. Whatever the mechanism of pain in these patients, their pain will require careful assessment and management, to insure the correct type and level of analgesia is given. The objective of this systematic review was the identification of studies that have investigated the efficacy of different analgesics on pain intensity or pain-related behavior during nursing home stay and at the end of life.
methodsA search using pain, pain treatment, and dementia MESH terms and keywords was conducted (October 15, 2015) in MEDLINE, EMBASE, PsychINFO, CINAHL, and Cochrane libraries.
resultsOur search yielded 3138 unique hits, published between 1990 and October 2015. We read titles and abstracts, identified 124 papers for full-text evaluation, and included 12 papers to reflect and synthesize the following questions: (1) Which pain assessment tools for people with dementia are responsive to change in pain intensity scores? (2) Which analgesics are efficacy-tested by controlled trials including people with dementia living in nursing homes, including at the end of life? (3) Which outcome measures have been used to identify pain, pain behavior, and/or treatment efficacy in people with dementia?
conclusionDespite increased use of analgesics, pain is still prevalent in people with dementia. Validated pain tools are available but not implemented and not fully tested on responsiveness to treatment. Official guidelines for pain assessment and treatment addressing people with dementia living in a nursing home are lacking. The efficacy of analgesic drug use on pain or neuropsychiatric behavior related to dementia has been hardly investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.